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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Opposite Effective Connectivity in the Posterior Cingulate and Medial Prefrontal Cortex between First-Episode Schizophrenic Patients with Suicide Risk and Healthy Controls
PLoS ONE, Volume 8, No. 5, Article e63477, Year 2013
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Description
Objective:The schizophrenic patients with high suicide risk are characterized by depression, better cognitive function, and prominent positive symptoms. However, the neurobiological basis of suicide attempts in schizophrenia is not clear. The suicide in schizophrenia is implicated in the defects in emotional process and decision-making, which are associated with prefrontal-cingulate circuit. In order to explore the possible neurobiological basis of suicide in schizophrenia, we investigated the correlation of prefrontal-cingulate circuit with suicide risk in schizophrenia via dynamic casual modelling.Method:Participants were 33 first-episode schizophrenic patients comprising of a high suicide risk group (N = 14) and a low suicide risk group (N = 19). A comparison group of healthy controls (N = 15) were matched for age, gender and education. N-back tasking functional magnetic resonance imaging data was collected.Results:Compared with healthy controls group, the two patients groups showed decreased task-related suppression during 2-back task state versus baseline state in the left posterior cingulate and medial prefrontal cortex; the hyper-connectivity from the left posterior cingulate cortex to the left medial prefrontal cortex existed in both schizophrenic patients groups, but hypo-connectivity in the opposite direction only existed in the schizophrenic patients group with high suicide risk.Conclusions:The hyper-connectivity from the left posterior cingulate cortex to the left medial prefrontal cortex may suggest that the abnormal effective connectivity was associated with risk for schizophrenia. The hypo-connectivity in the opposite direction may represent a possible correlate of increased vulnerability to suicide attempt. © 2013 Zhang et al.
Authors & Co-Authors
Zhang, Huiran
China, Changsha
Second Xiangya Hospital of Central South University
China, Zhengzhou
First Affiliated Hospital of Zhengzhou University
Wei, Xiaomei
China, Beijing
Institute of High Energy Physics, Chinese Academy of Sciences
Tao, Haojuan
China, Changsha
Second Xiangya Hospital of Central South University
Mwansisya, Tumbwene Elieza
China, Changsha
Second Xiangya Hospital of Central South University
Tanzania, Dodoma
The University of Dodoma
Pu, Weidan
China, Changsha
Second Xiangya Hospital of Central South University
He, Zhong
China, Changsha
Second Xiangya Hospital of Central South University
Hu, Aimin
China, Changsha
Second Xiangya Hospital of Central South University
Xu, Lin
China, Kunming
Kunming Institute of Zoology Chinese Academy of Sciences
Liu, Zhening
China, Changsha
Second Xiangya Hospital of Central South University
Shan, Baoci
China, Beijing
Institute of High Energy Physics, Chinese Academy of Sciences
Xue, Zhimin
China, Changsha
Second Xiangya Hospital of Central South University
Statistics
Citations: 40
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pone.0063477
e-ISSN:
19326203
Research Areas
Mental Health
Study Design
Quasi Experimental Study