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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A multicenter randomized trial of continuous versus intermittent β-lactam infusion in severe sepsis
American Journal of Respiratory and Critical Care Medicine, Volume 192, No. 11, Year 2015
Notification
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Description
Rationale: Continuous infusion of β-lactam antibiotics may improve outcomes because of time-dependent antibacterial activity compared with intermittent dosing. Objectives: To evaluate the efficacy of continuous versus intermittent infusion in patients with severe sepsis. Methods: We conducted a randomized controlled trial in 25 intensive care units (ICUs). Participants commenced on piperacillin-tazobactam, ticarcillin-clavulanate, or meropenem were randomized to receive the prescribed antibiotic via continuous or 30-minute intermittent infusion for the remainder of the treatment course or until ICU discharge. The primary outcome was the number of alive ICU-free days at Day 28. Secondary outcomes were 90-day survival, clinical cure 14 days post antibiotic cessation, alive organ failure-free days at Day 14, and duration of bacteremia. Measurements and Main Results: We enrolled 432 eligible participants with a median age of 64 years and an Acute Physiology and Chronic Health Evaluation II score of 20. There was no difference in ICU-free days: 18 days (interquartile range, 2-24) and 20 days (interquartile range, 3-24) in the continuous and intermittent groups (P = 0.38). There was no difference in 90-day survival: 74.3% (156 of 210) and 72.5% (158 of 218); hazard ratio, 0.91 (95% confidence interval, 0.63-1.31; P = 0.61). Clinical cure was 52.4% (111 of 212) and 49.5% (109 of 220); odds ratio, 1.12 (95% confidence interval, 0.77-1.63; P = 0.56). There was no difference in organ failure-free days (6 d; P = 0.27) and duration of bacteremia (0 d; P = 0.24). Conclusions: In critically ill patients with severe sepsis, there was no difference in outcomes between β-lactam antibiotic administration by continuous and intermittent infusion. Copyright © 2015 by the American Thoracic Society.
Authors & Co-Authors
Dulhunty, Joel M.
Australia, Brisbane
Royal Brisbane and Women's Hospital
Australia, Brisbane
The University of Queensland
Australia, Melbourne
Austin Hospital
Roberts, Jason A.
Australia, Brisbane
Royal Brisbane and Women's Hospital
Australia, Brisbane
The University of Queensland
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Davis, Joshua S.
Australia, Darwin
Charles Darwin University
Australia, Newcastle
John Hunter Hospital
Webb, Steve A.R.
Australia, Perth
Royal Perth Hospital
Australia, Perth
The University of Western Australia
Australia, Blacktown
Blacktown & Mount Druitt Hospital
United States, St. Louis
Washington University School of Medicine in St. Louis
Bellomo, Rinaldo
Australia, Melbourne
Austin Hospital
Australia, Clayton
Monash University
Gomersall, Charles David
Hong Kong
Prince of Wales Hospital Hong Kong
Hong Kong, Hong Kong
Chinese University of Hong Kong
Australia, Sydney
George Institute for Global Health
Eastwood, Glenn
Australia, Melbourne
Austin Hospital
Australia, Sydney
Prince of Wales Hospital
Myburgh, John A.
Australia, Sydney
George Institute for Global Health
Australia, Sydney
Unsw Sydney
Australia, Sydney
St George Hospital
Australia, Brisbane
Royal Brisbane and Women's Hospital
Paterson, David L.
Australia, Brisbane
Royal Brisbane and Women's Hospital
Australia, Brisbane
Uq Centre for Clinical Research
Starr, Therese
Australia, Brisbane
Royal Brisbane and Women's Hospital
Australia, Brisbane
The University of Queensland
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Paul, Sanjoy K.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Lipman, Jeffrey
Australia, Brisbane
Royal Brisbane and Women's Hospital
Australia, Brisbane
The University of Queensland
Peck, Leah
Australia, Melbourne
Austin Hospital
Young, Helen
Australia, Melbourne
Austin Hospital
Boschert, Catherine
Australia, Bendigo
Bendigo Hospital
Fletcher, Jason A.
Australia, Bendigo
Bendigo Hospital
Smith, Julie C.
Australia, Bendigo
Bendigo Hospital
Nand, Kiran
Australia, Blacktown
Blacktown & Mount Druitt Hospital
Sara, Treena
Australia, Blacktown
Blacktown & Mount Druitt Hospital
Australia, Toowoomba
Toowoomba Hospital
Rodgers, Helen J.
Australia, Canberra
Canberra Hospital
van Haren, Frank M.P.
Australia, Canberra
Canberra Hospital
Thomas, Karen George
Australia, Adelaide
Flinders Medical Centre
Bone, Allison
Australia, Geelong
Geelong Hospital
Cattigan, Claire
Australia, Geelong
Geelong Hospital
Elderkin, Tania D.
Australia, Geelong
Geelong Hospital
Salerno, Tania
Australia, Geelong
Geelong Hospital
Cameron, Robert J.
Australia, Gosford
Gosford Hospital
Ellis, Katrina
Australia, Gosford
Gosford Hospital
Soar, Natalie
Australia, Adelaide
Lyell Mcewin Health Service
Stuart, Janine
Australia, Brisbane
Royal Brisbane and Women's Hospital
Udy, Andrew A.
Australia, Brisbane
Royal Brisbane and Women's Hospital
Cooper, D. James
Australia, Hobart
Royal Hobart Hospital
McAllister, Richard E.
Australia, Hobart
Royal Hobart Hospital
Inskip, Deborah M.
Australia, Sydney
St George Hospital
Miller, Jennene J.
Australia, Sydney
St George Hospital
Knowles, Serena
Australia, Fitzroy
St. Vincent's Hospital Melbourne
Reynolds, Claire
Australia, Fitzroy
St. Vincent's Hospital Melbourne
Kong, Jing
Australia, Sydney
Westmead Hospital
Nayyar, Vineet
Australia, Sydney
Westmead Hospital
Whitehead, Christina
Australia, Sydney
Westmead Hospital
Leung, Patricia N.
Hong Kong
Prince of Wales Hospital Hong Kong
Gilder, Eileen
New Zealand, Auckland
Auckland City Hospital
McCarthy, Lianne W.
New Zealand, Auckland
Auckland City Hospital
McGuinness, Shay P.
New Zealand, Auckland
Auckland City Hospital
Parke, Rachael L.
New Zealand, Auckland
Auckland City Hospital
Benefield, Kirsten
New Zealand, Auckland
Auckland City Hospital
Chen, Yan
New Zealand, Auckland
Auckland City Hospital
McArthur, Colin J.
New Zealand, Auckland
Auckland City Hospital
Newby, Lynette
New Zealand, Auckland
Auckland City Hospital
Henderson, Seton J.
New Zealand, Christchurch
Christchurch Hospital new Zealand
Mehrtens, Jan E.
New Zealand, Christchurch
Christchurch Hospital new Zealand
Noble, Sascha
New Zealand, Christchurch
Christchurch Hospital new Zealand
Hunt, Anna L.
New Zealand, Wellington
Wellington Hospital, new Zealand
MacKle, Diane M.
New Zealand, Wellington
Wellington Hospital, new Zealand
Young, Paul Jeffrey
New Zealand, Wellington
Wellington Hospital, new Zealand
Kollef, Marin H.
Australia, Perth
Royal Perth Hospital
Turnidge, John D.
Australia, Adelaide
University of South Australia
Statistics
Citations: 178
Authors: 57
Affiliations: 37
Identifiers
Doi:
10.1164/rccm.201505-0857OC
ISSN:
1073449X
Research Areas
Environmental
Study Design
Case-Control Study
Study Approach
Quantitative