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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The value of human heart-type fatty acid binding protein in diagnosis of patients with acute chest pain
Egyptian Heart Journal, Volume 64, No. 4, Year 2012
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Description
Background: The aim was to determine the efficacy of heart-type fatty acid-binding protein (H-FABP) compared with routinely myoglobin (MYO), creatine kinase-MB (CK-MB) and cardiac troponin-I (cTn-I) in the early diagnosis of acute myocardial infarction (AMI) in patients presenting with acute chest pain. Methods and results: The patients were classified as AMI (n= 22), unstable angina (UA, n=. 20) and non-cardiac chest pain (NCCP, n= 15) within 3 h and 6 h of acute chest pain according to the American College/European Society of Cardiology; and normal healthy subjects (controls, n=. 10). Blood H-FABP levels were measured by ELISA and compared with cTn-I, CK-MB and MYO in all subjects. The diagnostic sensitivity, specificity and receiver operating characteristic (ROC) curve were evaluated. Serum H-FABP, MYO, CK-MB and cTn-I were significantly higher in AMI more than the UA, NCCP (non-AMI) and control groups within 6 h. However, Serum H-FABP, MYO and CK-MB were significantly elevated within 0-3 h and extend more within 3-6 h in AMI versus non-AMI. The cutoff value of H-FABP in AMI was 21.85. ng/ml within 3 h, and has diagnostic sensitivity (81.8%) equal to that of CK-MB and cTn-I but superior to that of MYO (72.7%). However, H-FABP has higher specificity (88.2%) equal to that of MYO but superior to that of CK-MB and cTn-I. This trend extends to within 6 h as well. Moreover, ROC curve areas for H-FABP were significantly higher (p< 0.05) than other biomarkers <6 h after the onset of chest pain. Conclusion: H-FABP can be used as a sensitive biomarker for myocardial injury in early stage. © 2012.
Authors & Co-Authors
Elmadbouh, Ibrahim
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Mahfouz, Riham
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Bayomy, Noha Rabie M.
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Faried, Walaa
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Ghanayem, Naglaa Mohamed
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Statistics
Citations: 10
Authors: 5
Affiliations: 1
Identifiers
Doi:
10.1016/j.ehj.2012.06.004
ISSN:
11102608
Research Areas
Noncommunicable Diseases
Violence And Injury