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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cytokine profiles in toxoplasmic and viral uveitis
Journal of Infectious Diseases, Volume 199, No. 8, Year 2009
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Description
Background. Uveitis is a major cause of visual impairment throughout the world. Analysis of cytokine profiles in aqueous humor specimens may provide insight into the physiopathological processes that underly retinal damage in this context. Methods. Using a multiplex assay, we determined the concentrations of 17 cytokines and chemokines in aqueous humor specimens obtained from patients with ocular toxoplasmosis or viral uveitis and compared these concentrations with those in specimens obtained from patients with noninfectious intermediate uveitis or cataract. Results. Five mediators (interleukin [IL]- 8, monocyte chemoattractant protein-1, tumor necrosis factor-α, IL-4, and IL-10) were detected in <50% of patients in all groups. In contrast, IL-5 and IL-12 were specific for ocular toxoplasmosis, and granulocyte monocyte colony-stimulating factor and IL-1 were specific for viral uveitis; these mediators could present specific markers for diagnostic purposes. Interferon-γ, IL-6, and macrophage inflammatory protein-1β were common markers of ocular toxoplasmosis and viral uveitis. IL-17 was a common marker of ocular toxoplasmosis and intermediate uveitis. Conclusions. Wefound specific cytokine profiles for each type of uveitis, with large interindividual variations and no etiological or clinical correlations. Ocular cytokine mapping contributes to a better understanding of the physiopathology of specific forms of uveitis and provides guidance for new targeted treatment. © 2009 by the Infectious Diseases Society of America.
Authors & Co-Authors
Lahmar, Ibtissem
France, Strasbourg
Université de Strasbourg
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Ahmed, Abou Bacar
France, Strasbourg
Université de Strasbourg
Abdelrahman, Tamer
France, Strasbourg
Université de Strasbourg
Guinard, Marie
France, Strasbourg
Université de Strasbourg
Babba, Hamouda
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Ben-Yahia, Salim
Tunisia, Monastir
Chu Fattouma-bourguiba
Kairallah, M.
Tunisia, Monastir
Chu Fattouma-bourguiba
Claude, Speeg Schatz
France, Strasbourg
Les Hôpitaux Universitaires de Strasbourg
Bourcier, Tristan
France, Strasbourg
Les Hôpitaux Universitaires de Strasbourg
Sauer, Arnaud
France, Strasbourg
Les Hôpitaux Universitaires de Strasbourg
Villard, Odile
France, Strasbourg
Université de Strasbourg
Pfaff, Alexander Wilhelm
France, Strasbourg
Université de Strasbourg
Mousli, Marc
France, Strasbourg
Université de Strasbourg
Garweg, Justus G.
Switzerland, Bern
University of Bern
Candolfi, Ermanno
France, Strasbourg
Université de Strasbourg
France, Strasbourg
Institut de Parasitologie et de Pathologie Tropicale
Statistics
Citations: 79
Authors: 15
Affiliations: 6
Identifiers
Doi:
10.1086/597478
ISSN:
00221899
Research Areas
Cancer
Health System And Policy