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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The DNA methylomes of serous borderline tumors reveal subgroups with malignant- or benign-like profiles
American Journal of Pathology, Volume 182, No. 3, Year 2013
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Description
Serous borderline tumors (SBOTs) are a challenging group of ovarian tumors positioned between benign and malignant disease. We have profiled the DNA methylomes of 12 low-grade serous carcinomas (LGSCs), 19 SBOTs, and 16 benign serous tumors (BSTs) across 27,578 CpG sites to further characterize the epigenomic relationship between these subtypes of ovarian tumors. Unsupervised hierarchical clustering of DNA methylation levels showed that LGSCs differ distinctly from BSTs, but not from SBOTs. Gene ontology analysis of genes showing differential methylation at linked CpG sites between LGSCs and BSTs revealed significant enrichment of gene groups associated with cell adhesion, cell-cell signaling, and the extracellular region, consistent with a more invasive phenotype of LGSCs compared with BSTs. Consensus clustering highlighted differences between SBOT methylomes and returned subgroups with malignant- or benign-like methylation profiles. Furthermore, a two-loci DNA methylation signature can distinguish between these SBOT subgroups with benign- and malignant-like methylation characteristics. Our findings indicate striking similarities between SBOT and LGSC methylomes, supporting a common origin and the view that LGSC may arise from SBOT. A subgroup of SBOTs can be classified into tumors with a benign- or a malignant-like methylation profile that may help in identifying tumors more likely to progress into LGSCs. Copyright © 2013 American Society for Investigative Pathology.
Authors & Co-Authors
Zeller, Constanze
United Kingdom, London
Imperial College London
Dai, Wei
United Kingdom, London
Imperial College London
Curry, Edward W.J.
United Kingdom, London
Imperial College London
Siddiq, Afshan
United Kingdom, London
School of Public Health
Walley, Andrew J.
United Kingdom, London
School of Public Health
Masrour, Nahal
United Kingdom, London
Imperial College London
Kitsou-Mylona, Isidora
United Kingdom, London
Imperial College London
Anderson, Gail
United Kingdom, London
Imperial College London
Ghaem-Maghami, Sadaf
United Kingdom, London
Imperial College London
Brown, Robert
United Kingdom, London
Imperial College London
El-Bahrawy, Mona A.
United Kingdom, London
Imperial College London
Egypt, Alexandria
Faculty of Medicine
Statistics
Citations: 14
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.1016/j.ajpath.2012.11.040
e-ISSN:
15252191
Research Areas
Cancer
Genetics And Genomics