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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Radiofrequency ablation of benign thyroid nodules: A prospective, multi-institutional North American experience
Surgery (United States), Volume 175, No. 1, Year 2024
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Description
Background: Radiofrequency ablation for benign thyroid nodules aims to achieve a volume reduction rate of ≥50%. However, factors that predict treatment success have not been defined in a large-scale study. Methods: A prospective cohort study of biopsy-proven benign thyroid nodules treated with radiofrequency ablation at 3 institutions was performed. Patient demographics, nodule sonographic features, procedural data, and nodule volume reduction were evaluated. Binary logistic regression analysis was performed to identify features associated with treatment response. Results: A total of 620 nodules were analyzed. The pooled median volume reduction rate at 12 months was 70.9% (interquartile range 52.9–86.6). At 1 year follow-up, 78.4% of nodules reached treatment success with a volume reduction rate ≥50%. The overall complication rate was 3.2% and included temporary voice changes (n = 14), vasovagal episodes (n = 5), nodule rupture (n = 3), and lightheadedness (n = 2). No permanent voice changes occurred. Four patients developed postprocedural hypothyroidism. Large baseline nodule volume (>20 mL) was associated with a lower rate of successful volume reduction (odds ratio 0.60 [0.37–0.976]). Large nodules achieved treatment success by 12-month follow-up at a rate of 64.5%, compared with 81.4% for small nodules and 87.2% for medium nodules. Conclusion: To our knowledge, this is the largest North American cohort of patients with benign thyroid nodules treated with radiofrequency ablation. Overall, radiofrequency ablation was an effective treatment option with a low risk of procedural complications. Large volume nodules (>20 mL) may be associated with a lower rate of successful reduction with radiofrequency ablation treatment. © 2023 Elsevier Inc.
Authors & Co-Authors
Russell, Jonathon Owen
United States, Baltimore
Johns Hopkins School of Medicine
Noel, Julia E.
United States, Stanford
Stanford University School of Medicine
Hussein, Mohammad Hosny
United States, New Orleans
Tulane University School of Medicine
Toraih, Eman Ali
United States, New Orleans
Tulane University School of Medicine
Egypt, Ismailia
Suez Canal University
Wolfe, Samantha A.
Canada, Toronto
University of Toronto
Omar, Mahmoud
United States, New Orleans
Tulane University School of Medicine
Issa, Peter P.
United States, New Orleans
Tulane University School of Medicine
Orloff, Lisa Ann
United States, Stanford
Stanford University School of Medicine
Tufano, Ralph Patrick
United States, Sarasota
Sarasota Memorial Health Care System
Kandil, Emad H.
United States, New Orleans
Tulane University School of Medicine
Statistics
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1016/j.surg.2023.07.046
ISSN:
00396060
Research Areas
Cancer
Health System And Policy
Study Design
Cohort Study
Case-Control Study
Study Approach
Quantitative