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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Proton-counting radiography for proton therapy: A proof of principle using CMOS APS technology
Physics in Medicine and Biology, Volume 59, No. 11, Year 2014
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Description
Despite the early recognition of the potential of proton imaging to assist proton therapy (Cormack 1963 J. Appl. Phys. 34 2722), the modality is still removed from clinical practice, with various approaches in development. For proton-counting radiography applications such as computed tomography (CT), the water-equivalent-path-length that each proton has travelled through an imaged object must be inferred. Typically, scintillator-based technology has been used in various energy/range telescope designs. Here we propose a very different alternative of using radiation-hard CMOS active pixel sensor technology. The ability of such a sensor to resolve the passage of individual protons in a therapy beam has not been previously shown. Here, such capability is demonstrated using a 36 MeV cyclotron beam (University of Birmingham Cyclotron, Birmingham, UK) and a 200 MeV clinical radiotherapy beam (iThemba LABS, Cape Town, SA). The feasibility of tracking individual protons through multiple CMOS layers is also demonstrated using a two-layer stack of sensors. The chief advantages of this solution are the spatial discrimination of events intrinsic to pixelated sensors, combined with the potential provision of information on both the range and residual energy of a proton. The challenges in developing a practical system are discussed. © 2014 Institute of Physics and Engineering in Medicine.
Authors & Co-Authors
Poludniowski, Gavin G.
United Kingdom, Guildford
University of Surrey
Allinson, Nigel M.
United Kingdom, Lincoln
University of Lincoln
Anaxagoras, Thalis
United Kingdom, London
Isdi Ltd
Esposito, Michela
United Kingdom, Guildford
University of Surrey
United Kingdom, Lincoln
University of Lincoln
Green, Stuart
United Kingdom, Birmingham
University of Birmingham
United Kingdom, Birmingham
University Hospitals Birmingham Nhs Foundation Trust
Manolopoulos, Spyros
United Kingdom, Coventry
University Hospitals Coventry and Warwickshire Nhs Trust
Nieto-Camero, Jaime J.
South Africa
Somerset West 7129, sa
Parker, David J.
United Kingdom, Birmingham
University of Birmingham
Price, Tony
United Kingdom, Birmingham
University of Birmingham
United Kingdom, Birmingham
University Hospitals Birmingham Nhs Foundation Trust
Evans, Philip
United Kingdom, Guildford
University of Surrey
Statistics
Citations: 48
Authors: 10
Affiliations: 7
Identifiers
Doi:
10.1088/0031-9155/59/11/2569
ISSN:
00319155
Research Areas
Cancer
Environmental
Health System And Policy