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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Childhood trauma and treatment outcomes during mood-stabilising treatment with lithium or quetiapine among outpatients with bipolar disorder
Acta Psychiatrica Scandinavica, Volume 145, No. 6, Year 2022
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Description
Background: Childhood trauma affects the course of mood disorders. Researchers are now considering childhood trauma as an influential factor in the treatment of mood disorders. However, the role of childhood trauma in the treatment of bipolar disorder remains understudied. Methods: The effect of childhood trauma on treatment outcomes was evaluated among participants randomised to treatment with lithium or quetiapine in the Clinical and Health Outcomes Initiatives in Comparative Effectiveness for Bipolar Disorder (Bipolar CHOICE) study by clinician assessment. Mixed effects linear regression models were used to analyse rates of improvement in symptom severity (assessed with the Bipolar Inventory of Symptoms Scale and the Clinical Global Impression Scale for Bipolar Disorder) and functional impairment (assessed with the Longitudinal Interval Follow-up Evaluation-Range of Impaired Functioning Tool). Results: A history of any childhood trauma was reported by 52.7% of the sample (N = 476). Although participants with a history of any childhood trauma presented with greater symptom severity and functional impairment at most study visits, participants with and without a history of any childhood trauma showed similar rates of improvement in symptom severity and functional impairment over the 24 weeks of treatment. Conclusion: This is the first study to explore the association between childhood trauma and treatment outcomes during treatment with lithium or quetiapine in the context of a randomised trial. In Bipolar CHOICE, a history of childhood trauma did not inhibit improvement in symptom severity or functional impairment. Nevertheless, these findings need replication across different settings. © 2022 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd.
Authors & Co-Authors
Dean, Olívia May
Australia, Geelong
Deakin University
Australia, Melbourne
The Florey
Cotton, Sue M.
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
Thase, Michael E.
United States, Philadelphia
University of Pennsylvania
Calabrese, Joseph R.
United States, Cleveland
Case Western Reserve University
Deckersbach, Thilo
Germany, Steinfurt
Fachhochschule Münster - Abteilung Steinfurt
Tohen, Mauricio F.
United States, Albuquerque
Unm Health Sciences Center
Iosifescu, Dan Vlad
United States, Orangeburg
Nathan S. Kline Institute for Psychiatric Research
Berk, Michael
Australia, Geelong
Deakin University
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
The Florey
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Royal Melbourne Hospital
Turner, Alyna
Australia, Geelong
Deakin University
Australia, Callaghan
The University of Newcastle, Australia
Nierenberg, Andrew Alan
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
Statistics
Citations: 5
Authors: 10
Affiliations: 22
Identifiers
Doi:
10.1111/acps.13420
ISSN:
0001690X
Research Areas
Maternal And Child Health
Mental Health
Study Design
Cohort Study