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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Short communication: Phylogenetic characterization of HIV type 1 CRF01-AE V3 envelope sequences in pregnant women in northern Vietnam
AIDS Research and Human Retroviruses, Volume 28, No. 8, Year 2012
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Description
Characterization of HIV-1 strains is important for surveillance of the HIV-1 epidemic. In Vietnam HIV-1-infected pregnant women often fail to receive the care they are entitled to. Here, we analyzed phylogenetically HIV-1 env sequences from 37 HIV-1-infected pregnant women from Ha Noi (n=22) and Hai Phong (n=15), where they delivered in 2005-2007. All carried CRF01-AE in the gp120 V3 region. In 21 women CRF01-AE was also found in the reverse transcriptase gene. We compared their env gp120 V3 sequences phylogenetically in a maximum likelihood tree to those of 198 other CRF01-AE sequences in Vietnam and 229 from neighboring countries, predominantly Thailand, from the HIV-1 database. Altogether 464 sequences were analyzed. All but one of the maternal sequences colocalized with sequences from northern Vietnam. The maternal sequences had evolved the least when compared to sequences collected in Ha Noi in 2002, as shown by analysis of synonymous and nonsynonymous changes, than to other Vietnamese sequences collected earlier and/or elsewhere. Since the HIV-1 epidemic in women in Vietnam may still be underestimated, characterization of HIV-1 in pregnant women is important to observe how HIV-1 has evolved and follow its molecular epidemiology. © Copyright 2012, Mary Ann Liebert, Inc. 2012.
Authors & Co-Authors
Caridha, Rozina
Sweden, Stockholm
Karolinska Institutet
Ha, Tran Thi Thanh
Sweden, Stockholm
Karolinska Institutet
Viet Nam, Hanoi
National Institute of Hygiene and Epidemiology Hanoi
Viet Nam, Hanoi
International Livestock Research Institute - Viet Nam Country Office
Gaseitsiwe, Simani
Sweden, Stockholm
Karolinska Institutet
Sweden, Solna
Public Health Agency of Sweden
Anh, Nguyen Mai
Unknown Affiliation
Bao, Nguyen Huy
Unknown Affiliation
Hien, Nguyen Tran
Viet Nam, Hanoi
National Institute of Hygiene and Epidemiology Hanoi
Cam, Phung Dac
Viet Nam, Hanoi
National Institute of Hygiene and Epidemiology Hanoi
Chiodi, Francesca
Sweden, Stockholm
Karolinska Institutet
Ehrnst, Anneka C.
Sweden, Stockholm
Karolinska Institutet
Statistics
Citations: 1
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1089/aid.2011.0033
ISSN:
19318405
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Participants Gender
Female