Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Novel association between sperm reactive oxygen species production, sperm morphological defects, and the sperm deformity index
Fertility and Sterility, Volume 81, No. 2, Year 2004
Notification
URL copied to clipboard!
Description
Objective: To examine the relationship between sperm reactive oxygen species (ROS) production and sperm morphology in a group of infertile men and healthy fertile donors. Design: A prospective clinical study. Setting: Male infertility clinic, Glickman Urological Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, and the Reproductive Medicine Unit, Liverpool Women's Hospital, United Kingdom. Patient(s): Thirty-nine infertile men and 13 healthy fertile donors (control). Intervention(s): Standard semen analysis, seminal leukocyte concentration, assessment of sperm morphology, and measurement of sperm ROS production. Main Outcome Measure(s): Levels of sperm ROS production, percentages of different sperm morphological abnormalities, and the sperm deformity index (SDI) scores. Result(s): A significant negative correlation was observed between sperm ROS production and the proportion of sperm with normal morphology and borderline morphology. Reactive oxygen species production was positively correlated with the proportion of sperm with amorphous heads, damaged acrosomes, midpiece defects, cytoplasmic droplets, tail defects, and SDI scores. Logistic regression analysis identified a two-variable model including SDI and percentage sperm motility, which correctly identified 84% of individuals with high seminal ROS and 85% of individuals with low seminal ROS. The model had an overall accuracy of 85%. Conclusion(s): The standard semen analysis to assess sperm motility, sperm morphology, and the SDI scores is a useful tool in identifying infertile men with high seminal ROS in infertility clinics where facilities for measuring levels of seminal ROS are not available. © 2004 by American Society for Reproductive Medicine.
Authors & Co-Authors
Aziz, Nabil F.
United Kingdom, Liverpool
University of Liverpool
Saleh, Ramadan Abdou
United States, Cleveland
Cleveland Clinic Foundation
Egypt, Sohag
Faculty of Medicine
Sharma, Rakesh Kumar
United States, Cleveland
Cleveland Clinic Foundation
Lewis-Jones, Iwan
United Kingdom, Liverpool
University of Liverpool
Esfandiari, Navid
United States, Cleveland
Cleveland Clinic Foundation
Canada, Toronto
Toronto Center for Assisted Reproductive Technologies
Thomas, Anthony Joseph
United States, Cleveland
Cleveland Clinic Foundation
Agarwal, Ashok K.
United States, Cleveland
Cleveland Clinic Foundation
Statistics
Citations: 302
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/j.fertnstert.2003.06.026
ISSN:
00150282
Research Areas
Health System And Policy
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Cohort Study
Study Approach
Quantitative
Participants Gender
Male
Female