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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
In vitro pharmacological and toxicological effects of norterpene peroxides isolated from the red sea sponge diacarnus erythraeanus on normal and cancer cells
Journal of Natural Products, Volume 76, No. 9, Year 2013
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Description
Eight cyclic peroxide norterpenoids, compounds 1-8, have been isolated and characterized from the Red Sea sponge Diacarnus erythraeanus, including two new norsesterterpene derivatives (3, 4). Among these metabolites, (-)-muqubilin A (5) (nine cell lines analyzed) and the new compounds 3 and 4 (seven cell lines analyzed) displayed mean IC50 growth inhibitory concentrations in vitro of <10 μM, while the remaining compounds (1, 6-8) were inactive in these cancer cell lines. Compound 5 displayed no selectivity between normal and cancer cells in terms of in vitro growth inhibition. Quantitative video microscopy analysis carried out on (-)-muqubilin A-treated cells validated the data obtained by means of the MTT colorimetric assay, while flow cytometry analysis revealed ROS production but no induction of apoptosis in cancer cells. © 2013 The American Chemical Society and American Society of Pharmacognosy.
Authors & Co-Authors
Lefranc, Florence
Belgium, Brussels
Hôpital Erasme
Nuzzo, Genoveffa
Italy, Pozzuoli
Istituto Di Chimica Biomolecolare, Pozzuoli
Hamdy, Nehal Aly
Egypt, Giza
National Research Centre
Fakhr, Issa M.I.
Egypt, Giza
National Research Centre
Moreno Y Banuls, Laetitia
Belgium, Brussels
Université Libre de Bruxelles
Van Goietsenoven, Gwendoline
Belgium, Brussels
Université Libre de Bruxelles
Villani, Guido
Italy, Pozzuoli
Istituto Di Chimica Biomolecolare, Pozzuoli
Mathieu, Véronique
Belgium, Brussels
Université Libre de Bruxelles
van Soest, Rob W.M.V.
Netherlands, Leiden
Naturalis Biodiversity Center
Kiss, Robert
Belgium, Brussels
Université Libre de Bruxelles
Ciavatta, M. L.
Italy, Pozzuoli
Istituto Di Chimica Biomolecolare, Pozzuoli
Statistics
Citations: 40
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1021/np400107t
ISSN:
01633864
e-ISSN:
15206025
Research Areas
Cancer
Study Approach
Quantitative