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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Efficacy of artemisinin combination therapy for the treatment of uncomplicated falciparum malaria in Nigerian children
Journal of Infection in Developing Countries, Volume 7, No. 12, Year 2013
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Description
Introduction: The development and spread of Plasmodium falciparum resistance to most commonly used antimalarials remain a major challenge in the control of malaria. Constant monitoring of drug efficacy is an important tool in establishing rational antimalarial drug policies. Methodology: A randomized comparative study was conducted at the Wesley Guild Hospital, Ilesa, Nigeria between February 2010 and September 2011 comparing the efficacy and safety of artemether-lumefantrine (Coartem) and fixed dose of artesunate plus amodiaquine (Larimal) in the treatment of uncomplicated P. falciparum malaria in children betweem 6 and 144 months of age. P. falciparum malaria parasitemia was assessed by microscopy and rapid diagnostic test. Drugs were administered according to age for three days under supervision. The primary efficacy endpoint was a day 28 PCR-corrected parasitological cure. Results: A total of 182 patients were enrolled in the two treatment groups, Coartem (n = 101) and Larimal (n = 81), and tested after 28 days. In the intention-to-treat population, Coartem (n= 101) and Larimal (n= 81) had a PCR-corrected cure rate of 98% and 100% respectively, while in the per-protocol population, Coartem (n = 89) and Larimal (n = 71) both had a PCR-corrected cure rate of 100% at day 28. Although parasite and fever clearance time was faster in the Larimal group, no significant difference was observed between the two drugs. No serious adverse effects were reported. Conclusion: Five years after being introduced in Nigeria, both Coartem and Larimal have been shown to be safe and highly effective in the treatment of uncomplicated P. falciparum malaria in children. © 2013 Ojurongbe et al.
Authors & Co-Authors
Ojurongbe, Olusola Daniel
Nigeria, Ogbomoso
Ladoke Akintola University of Technology
Lawal, Olubunmi Adeola
Nigeria, Ilesa
Wesley Guild Hospital
Abiodun, Oyindamola Olajumoke
Nigeria, Ibadan
University of Ibadan
Okeniyi, John Akintunde
Nigeria, Ilesa
Wesley Guild Hospital
Oyeniyi, Ayobami J.
Nigeria, Ilesa
Wesley Guild Hospital
Oyelami, Oyeku Akibu
Nigeria, Ilesa
Wesley Guild Hospital
Statistics
Citations: 17
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.3855/jidc.3058
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Nigeria