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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
The synthesis and antiparasitic activity of aryl- and ferrocenyl-derived thiosemicarbazone ruthenium(ii)-arene complexes
Dalton Transactions, Volume 42, No. 13, Year 2013
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Description
A series of aryl-functionalized and ferrocenyl monothiosemicarbazone compounds (L1-L4) were synthesized in moderate yields via a general Schiff-base condensation reaction. The thiosemicarbazone (TSC) ligands were reacted with the ruthenium dimer [Ru(Ar)(μ-Cl)Cl]2 (Ar = benzene; p-cymene) to yield a series of cationic mononuclear ruthenium(ii)-arene thiosemicarbazone complexes of the general type [Ru(Cl)(TSC)(Ar)]Cl (1-8). The thiosemicarbazone ligands act as bidentate chelating ligands that coordinate to the ruthenium(ii) ion via the imine nitrogen and the thione sulfur atoms. The thiosemicarbazone ligands, as well as their metal complexes, were characterized by NMR, IR spectroscopy and ESI+-mass spectrometry. The molecular structure of the mononuclear ruthenium(ii)-arene thiosemicarbazone complex (6) was determined by single-crystal X-ray diffraction analysis. The ruthenium(ii)-arene thiosemicarbazone complexes were further evaluated for their in vitro antiparasitic activities against the Plasmodium falciparum chloroquine-sensitive (NF54) and chloroquine-resistant (Dd2) strains, as well as the G3 strain of Trichomonas vaginalis. © The Royal Society of Chemistry 2013.
Authors & Co-Authors
Adams, Muneebah
South Africa, Cape Town
University of Cape Town
Li, Yiqun
South Africa, Cape Town
University of Cape Town
Khot, Heena
South Africa, Cape Town
University of Cape Town
de Kock, Carmen A.
South Africa, Observatory
Groote Schuur Hospital
Smith, Peter John
South Africa, Observatory
Groote Schuur Hospital
Land, Kirkwood M.
United States, Stockton
University of the Pacific, California
Chibale, Kelly
South Africa, Cape Town
University of Cape Town
Smith, Gregory S.
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 93
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1039/c3dt32740j
ISSN:
14779226
e-ISSN:
14779234