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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
International seroepidemiology of adenovirus serotypes 5, 26, 35, and 48 in pediatric and adult populations
Vaccine, Volume 29, No. 32, Year 2011
Notification
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Description
Recombinant adenovirus serotype 5 (rAd5) vaccine vectors for HIV-1 and other pathogens have been shown to be limited by high titers of Ad5 neutralizing antibodies (NAbs) in the developing world. Alternative serotype rAd vectors have therefore been constructed. Here we report Ad5, Ad26, Ad35, and Ad48 NAb titers in 4381 individuals from North America, South America, sub-Saharan Africa, and Southeast Asia. As expected, Ad5 NAb titers were both frequent and high magnitude in sub-Saharan Africa and Southeast Asia. In contrast, Ad35 NAb titers proved infrequent and low in all regions studied, and Ad48 NAbs were rare in all regions except East Africa. Ad26 NAbs were moderately common in adults in sub-Saharan Africa and Southeast Asia, but Ad26 NAb titers proved markedly lower than Ad5 NAb titers in all regions, and these relatively low Ad26 NAb titers did not detectably suppress the immunogenicity of 4×10 10vp of a rAd26-Gag/Pol/Env/Nef vaccine in rhesus monkeys. These data inform the clinical development of alternative serotype rAd vaccine vectors in the developing world. © 2011 Elsevier Ltd.
Authors & Co-Authors
Barouch, Dan H.
United States, Boston
Beth Israel Deaconess Medical Center
United States, Cambridge
Massachusetts Institute of Technology
Kik, Sandra V.
Netherlands, Leiden
Crucell nv
Weverling, Gerrit Jan
Netherlands, Leiden
Crucell nv
Dilan, Rebecca
United States, Boston
Beth Israel Deaconess Medical Center
King, Sharon L.
United States, Boston
Beth Israel Deaconess Medical Center
Maxfield, Lori F.
United States, Boston
Beth Israel Deaconess Medical Center
Clark, Sarah
United States, Boston
Beth Israel Deaconess Medical Center
Ng'ang'a, David
United States, Boston
Beth Israel Deaconess Medical Center
Brandariz, Kara L.
United States, Boston
Beth Israel Deaconess Medical Center
Abbink, Peter
United States, Boston
Beth Israel Deaconess Medical Center
Sinangil, Faruk M.
United States, San Francisco
Global Solutions for Infectious Diseases
De Bruyn, Guy
South Africa, Johannesburg
University of the Witwatersrand
Gray, Glenda E.
South Africa, Johannesburg
University of the Witwatersrand
Roux, Surita
South Africa, Cape Town
University of Cape Town
Bekker, Linda-Gail Gail
South Africa, Cape Town
University of Cape Town
Dilraj, Athmanundh
South Africa, Tygerberg
South African Medical Research Council
Kibuuka, Hannah N.
Uganda, Kampala
Makerere University
Robb, Merlin Lee
United States, Silver Spring
Walter Reed Army Institute of Research
Michael, Nelson L.
United States, Silver Spring
Walter Reed Army Institute of Research
Anzala, Aggrey Omu
Kenya, Nairobi
University of Nairobi
Amornkul, Pauli N.
United States, New York
International Aids Vaccine Initiative
Gilmour, Jill W.
United States, New York
International Aids Vaccine Initiative
United Kingdom, London
Imperial College London
Hural, John A.
United States, Seattle
Fred Hutchinson Cancer Research Center
Buchbinder, Susan P.
United States, San Francisco
San Francisco Department of Public Health
Seaman, Michael S.
United States, Boston
Beth Israel Deaconess Medical Center
Dolin, Raphael
United States, Boston
Beth Israel Deaconess Medical Center
Baden, Lindsey Robert R.
United States, Boston
Brigham and Women's Hospital
Carville, Angela A.L.
United States, Southborough
New England Regional Primate Research Center
Mansfield, Keith G.
United States, Southborough
New England Regional Primate Research Center
Pau, Maria Grazia
Netherlands, Leiden
Crucell nv
Goudsmit, Jaap
Netherlands, Leiden
Crucell nv
Statistics
Citations: 263
Authors: 31
Affiliations: 16
Identifiers
Doi:
10.1016/j.vaccine.2011.05.025
ISSN:
0264410X
e-ISSN:
18732518
Research Areas
Infectious Diseases
Study Locations
Multi-countries