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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Neurological sequelae in survivors of cerebral malaria
Pan African Medical Journal, Volume 15, Article 88, Year 2013
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Description
Introduction: Cerebral malaria is a common cause of neurological sequelae and death in childhood. Information on persistent neurological sequelae post hospital discharge and their predisposing factors are scarce. Methods: This is a prospective study describing persisting neurological impairments post discharge among children treated for cerebral malaria. In addition the study was designed to investigate the frequency of persistent neurologic deficits and the risk factors for their persistence in these patients. The case records of 160 patients treated for CM at the Paediatrics Department of University College Hospital, Ibadan from January 2004 to November 2006 were reviewed to recruit cases. Recruited survivors were then followed up for information concerning the presence and persistence of neurological sequelae. Results: A total of 160 children aged 9 months to 134 months were admitted and treated for CM during the study period. One hundred and thirty one (81.9%) survived while 29 (18.1%) died. The 131 survivors of cerebral malaria consisted of 64 boys and 67 girls. Neurological sequelae occurred in 13.7% of survivors of cerebral malaria at discharge and 4.6% at follow up. Six children with neurological deficits at discharge had persistence of deficits 6 months post-hospital discharge and one at 24 months. No associations were found between hypoglycemia, anemia, age, sex and multiplicity of convulsions, and persistence of neurologic sequelae. The persisting neurologic deficits among survivors at follow up were: memory impairment (1.5%), seizure disorders (0.8%), visual impairment (0.8%), speech impairment (0.8%), monoparesis (0.8%) and hyperactivity (0.8%) at follow up. The longest persisting sequelae lasted for at least 24 months. Conclusion: Neurologic deficits are not uncommon complications of CM. Neurologic sequelae may persist for as long as 24 months or more in survivors of childhood CM. There is no association between the risk factors for neurologic deficits and persistent neurologic sequelae. © Isaac Oludare Oluwayemi et al.
Authors & Co-Authors
Oluwayemi, Isaac Oludare
Nigeria, Ado-ekiti
Ekiti State University
Brown, Biobele Jotham
Nigeria, Ibadan
University College Hospital, Ibadan
Oyedeji, Olusola Adetunji
Nigeria, Osogbo
Ladoke Akintola University Teaching Hospital
Oluwayemi, Margaret Adefiola
Nigeria, Ibadan
College of Medicine, University of Ibadan
Statistics
Citations: 45
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.11604/pamj.2013.15.88.1897
ISSN:
19378688
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Participants Gender
Male
Female