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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Doubly linked, A-type proanthocyanidin trimer and other constituents of Ixora coccinea leaves and their antioxidant and antibacterial properties
Phytochemistry, Volume 71, No. 17-18, Year 2010
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Description
Phytochemical investigation of the ethyl acetate fraction of the methanol extract of the leaves of Ixora coccinea led to the isolation and identification of an A-type trimeric proanthocyanidin epicatechin-(2β → O → 7, 4β → 8)-epicatechin-(5 → O → 2β, 6 → 4β)-epicatechin named ixoratannin A-2 along with seven known compounds, epicatechin, procyanidin A2, cinnamtannin B-1, and four flavon-3-ol rhamnosides viz: kaempferol-7-O-α-l-rhamnnoside, kaempferol-3-O-α-l-rhamnoside, quercetin-3-O-α-l-rhamnopyranoside, and kaempferol-3,7-O-α-l- dirhamnoside. The structures were elucidated by the application of IR, UV, MS, 1D-, and 2D-NMR spectroscopic analyses and by comparison with literature data. Antioxidant evaluation of isolated compounds revealed that ixoratannin A-2 and cinnamtannin B-1 were the most active compounds in DPPH, inhibition of lipid peroxidation and nitric oxide radical scavenging assays. Antibacterial activities were assessed by means of agar-diffusion assays using Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus subtilis. All tested compounds inhibited the growth of B. subtilis, while only epicatechin and quercetin-3-O-α-l-rhamnopyranoside inhibited the growth of E. coli. © 2010 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Idowu, Thomas Oyebode
Nigeria, Ife
Obafemi Awolowo University
Ogundaini, Abiodun Oguntuga
Nigeria, Ife
Obafemi Awolowo University
Salau, Abiola Oladimeji
Nigeria, Ife
Obafemi Awolowo University
Obuotor, E. M.
Nigeria, Ife
Obafemi Awolowo University
Bezabih, Merhatibeb
Botswana, Gaborone
University of Botswana
Abegaz, Berhanu Molla
Botswana, Gaborone
University of Botswana
Statistics
Citations: 79
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.phytochem.2010.08.018
ISSN:
00319422