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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Familial aggregation of nasal conditioning capacity
Journal of Applied Physiology, Volume 103, No. 3, Year 2007
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Description
In our previous studies on nasal conditioning, we observed a large variability among individuals to condition inspired air. Although we previously investigated various physiological parameters (age, sex, nasal mucosal temperature, heart rate, blood pressure, and nasal volume) that might underlie these differences, we have been unable to explain this variability. Many proteins and molecules, which are under genetic control and could affect nasal conditioning, are involved in water transport,. In this study, we hypothesized that familial factors may contribute to the differences in nasal conditioning capacity (NCC). We performed a prospective study of 47 sibling pairs. Cold dry air was delivered to the nose, and the total water gradient (TWG) was calculated to determine the NCC. We found a highly significant intraclass correlation of 0.53 (P < 0.0001) between sibling pairs for the TWG. These results suggest that there is a familial basis for nasal conditioning and a large enough genetic component to search for genes explaining the observed correlation. Copyright © 2007 the American Physiological Society.
Authors & Co-Authors
Sahin-Yilmaz, Asli
United States, Chicago
The University of Chicago
Turkey, Istanbul
I. Kbb Kliniǧi
Pinto, Jayant Marian
United States, Chicago
The University of Chicago
DeTineo, Marcy
United States, Chicago
The University of Chicago
Elwany, Samy S.
United States, Chicago
The University of Chicago
Egypt, Alexandria
Faculty of Medicine
Naclerio, Robert M.
United States, Chicago
The University of Chicago
Statistics
Citations: 7
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1152/japplphysiol.00299.2007
ISSN:
87507587
e-ISSN:
15221601
Research Areas
Environmental
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cohort Study