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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Analgesic and anti-inflammatory effects of the methanol stem bark extract of Prosopis africana
Pharmaceutical Biology, Volume 48, No. 3, Year 2010
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Description
Prosopis africana (Guill. & Perr.) Taub. (Mimosoideae) is a shrub used for menstrual and general body pain in Nupe land in north central Nigeria. In this study, the methanol extract of the stem bark of Prosopis africana (at doses of 62.5, 125, and 250mg/kg) was evaluated for analgesic and anti-inflammatory activities using acetic acid-induced writhing assay and carrageenan-induced inflammation in rats. The extract significantly (P <0.05) attenuated the acetic acid-induced writhing with the highest activity observed at the highest dose, 250mg/kg (76.89%) comparable to that of piroxicam (83.16%) the standard agent used. In the carrageenan-induced inflammation assay, the extract showed significant anti-inflammatory activity (P <0.001) from the third hour. The preliminary phytochemical screening revealed the presence of flavonoids, saponins, carbohydrates, cardiac glycosides, tannins, and alkaloids. The oral median lethal dose was found to be 3807.9mg/kg in mice and > 5000mg/kg in rats. This study supports the folkloric claim of the use of Prosopis africana in the management of pain. © 2010 Informa UK Ltd.
Authors & Co-Authors
Ayanwuyi, Lydia O.
Nigeria, Zaria
Ahmadu Bello University
Yaro, Abdullahi Hamza
Nigeria, Kano
Bayero University
Abodunde, Olajumoke M.
Nigeria, Zaria
Ahmadu Bello University
Statistics
Citations: 33
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.3109/13880200903121006
ISSN:
13880209
e-ISSN:
17445116
Research Areas
Health System And Policy
Noncommunicable Diseases
Sexual And Reproductive Health
Study Locations
Nigeria