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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Variation in delayed hypersensitivity in onchocerciasis
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 72, No. 4, Year 1978
Notification
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Description
Soluble antigen preparations were made from Onchocerca volvulus adults recovered from subcutaneous nodules, and from Necator americanus third-stage larvae. Intradermal skin tests were carried out on a total of 100 individuals clinically classified as having either the generalized form of onchocerciasis (86 cases), or the localized sowda form (14 cases). 91 of the people studied produced immediate reactions to the onchocercal antigen, but only those with sowda showed delayed reactions, though one person with generalized disease showed a doubtful delayed reaction. Reactions to N. americanus antigen, both immediate and delayed, were seen in both forms of the disease. The lack of delayed skin reaction in the generalized form of onchocerciasis is discussed, and a comparison is made with other diseases. Preliminary evidence for the existence of a true spectrum of clinical and immunological forms of onchocerciasis is suggested by one case in this study. © 1978 Oxford university press.
Authors & Co-Authors
Bartlett, Anne
United Kingdom, London
Zoological Society of London
Turk, J.
United Kingdom, London
The Royal College of Surgeons of England
Ngu, Jacob L.
Cameroon, Yaounde
Université de Yaoundé I
MacKenzie, Charles D.
United Kingdom, London
Mrc National Institute for Medical Research
Fuglsang, Harald
Cameroon, Yaounde
Medical Research Centre
Anderson, John
Cameroon, Yaounde
Medical Research Centre
Fuglsang, H.
Unknown Affiliation
Anderson, J.
Unknown Affiliation
Statistics
Citations: 61
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1016/0035-9203(78)90130-X
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Infectious Diseases