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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Association of In Utero sensitization to Schistosoma haematobium with enhanced cord blood IgE and increased frequencies of CD5-B cells in African newborns
American Journal of Tropical Medicine and Hygiene, Volume 86, No. 4, Year 2012
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Description
This study investigated in utero priming as a consequence of maternal parasitic infections. Cord blood plasma samples of 63 African newborns were assessed by enzyme-linked immunosorbent assay for their content of total and schistosome-specific or filaria-specific IgE and IgG4. The frequencies of lymphocyte phenotypes in cord blood were also determined by using flow cytometry, and were compared with those of European newborns. We found significantly increased schistosome soluble egg antigen (SEA)-specific IgE in cord plasma of those born to mothers with schistosome infections and correlations between fetal and maternal SEA-specific and filaria antigen-specific IgE. These data are evidence for in utero priming of the fetal immune system to maternal helminth infections. Furthermore, we show significantly enhanced percentages of CD5- B cells in African newborns cord blood compared with Europeans, which is consistent with earlier maturation of the African fetal immune system. Copyright © 2012 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Seydel, Larsen S.
Germany, Dortmund
St.-johannes-hospital Dortmund
Petelski, Annika
Gabon
Hôpital du Dr. Albert Schweitzer
Germany, Tubingen
Eberhard Karls Universität Tübingen
van Dam, Govert Jan
Netherlands, Leiden
Leids Universitair Medisch Centrum
van der Kleij, Desirée
Netherlands, Amsterdam
Sanquin Diagnostiek
Kruize-Hoeksma, Yvonne C.M.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Luty, A. J.F.
France, Marseille
Ird Institut de Recherche Pour le Developpement
Yazdanbakhsh, Maria M.
Gabon
Hôpital du Dr. Albert Schweitzer
Netherlands, Leiden
Leids Universitair Medisch Centrum
Kremsner, Peter G.
Gabon
Hôpital du Dr. Albert Schweitzer
Germany, Tubingen
Eberhard Karls Universität Tübingen
Statistics
Citations: 23
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.4269/ajtmh.2012.11-0463
ISSN:
00029637
Research Areas
Health System And Policy
Maternal And Child Health