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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
DNA methylation at a nutritionally sensitive region of the PAX8 gene is associated with thyroid volume and function in Gambian children
Science Advances, Volume 7, No. 45, Article eabj1561, Year 2021
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Description
PAX8 is a key thyroid transcription factor implicated in thyroid gland differentiation and function, and PAX8 gene methylation is reported to be sensitive to the periconceptional environment. Using a novel recall-by-epigenotype study in Gambian children, we found that PAX8 hypomethylation at age 2 years is associated with a 21% increase in thyroid volume and an increase in free thyroxine (T4) at 5 to 8 years, the latter equivalent to 8.4% of the normal range. Free T4 was associated with a decrease in DXA-derived body fat and bone mineral density. Furthermore, offspring PAX8 methylation was associated with periconceptional maternal nutrition, and methylation variability was influenced by genotype, suggesting that sensitivity to environmental exposures may be under partial genetic control. Together, our results demonstrate a possible link between early environment, PAX8 gene methylation and thyroid gland development and function, with potential implications for early embryonic programming of thyroid-related health and disease. Copyright © 2021 The Authors, some rights reserved;
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8570597/bin/sciadv.abj1561_sm.pdf
Authors & Co-Authors
Candler, Toby
United Kingdom, London
Medical Research Council
Kessler, Noah J.
United Kingdom, Cambridge
University of Cambridge
Ward, Kate Anna
United Kingdom, London
Medical Research Council
United Kingdom, Southampton
Mrc Lifecourse Epidemiology Unit
James, Philip T.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Laritsky, Eleonora
United States, Washington, D.c.
United States Department of Agriculture
Baker, Maria S.
United States, Washington, D.c.
United States Department of Agriculture
Dyer, Roger A.
Canada, Vancouver
Bc Children's Hospital Research Institute
Elango, Rajavel
Canada, Vancouver
Bc Children's Hospital Research Institute
Jeffries, David J.
United Kingdom, London
Medical Research Council
Waterland, R. A.
United States, Washington, D.c.
United States Department of Agriculture
United States, Houston
Baylor College of Medicine
Moore, Sophie E.
United Kingdom, London
Medical Research Council
United Kingdom, London
King's College London
Prentice, Andrew M.
United Kingdom, London
Medical Research Council
Silver, Matt J.
United Kingdom, London
Medical Research Council
Statistics
Citations: 9
Authors: 13
Affiliations: 9
Identifiers
Doi:
10.1126/sciadv.abj1561
ISSN:
23752548
Research Areas
Food Security
Genetics And Genomics
Maternal And Child Health