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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Clinical Studies of Iron Chelators in Malaria
Acta Haematologica, Volume 95, No. 1, Year 1996
Notification
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Description
In 75 Zambian and Thai subjects with mild to moderate infection with Plasmodium falciparum or Plasmodium vivax, 3-day infusions of desferrioxamine B (100 mg/kg/day) as a single agent enhanced the clearance of asexual peripheral blood parasites, but recrudescence occurred in most subjects. In 83 Zambian children with cerebral malaria who were randomized to receive desferrioxamine B or placebo in addition to standard quinine-based therapy as part of a prospective double-blind trial, both parasite clearance and recovery from coma were faster with administration of the iron chelator. Retrospective studies in the children with cerebral malaria raised the possibility that, in addition to withholding iron from the parasite, desferrioxamine B may have enhanced the T helper 1 immune response and protected against iron-mediated peroxidant cerebral tissue damage. © 1996 S. Karger AG, Basel.
Authors & Co-Authors
Mabeza, George F.
South Africa, Johannesburg
University of the Witwatersrand
Biemba, Godfrey
Zambia, Choma
Macha Mission Hospital
Gordeuk, Victor R.
United States, Washington, D.c.
George Washington University Medical Center
Statistics
Citations: 44
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1159/000203953
ISSN:
00015792
e-ISSN:
14219662
Research Areas
Disability
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study