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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The prevalence of hepatitis B virus markers in a cohort of students in Bangui, Central African Republic
BMC Infectious Diseases, Volume 10, Article 226, Year 2010
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Description
Background: Hepatitis B virus (HBV) is the major cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. The global epidemiological scenario of HBV infection has been changing rapidly over the last two decades due to an effective immunization programme initiated by the World Health Organization. The objective of this study is to estimate the prevalence of HBV in apparently healthy young people and to identify the risk factors of transmission of the HBV among this population in Bangui.Methods: Dried blood Spots from 801 adolescent high school and young adult university students were prepared by spotting a drop of whole blood (4 spots) from the same fingerprick onto Whatman filter paper. A blood sample aliquot eluted from DBS was then processed with commercial ELISA tests (Abbott Murex, Dartfort, UK) to detect HBsAg antigen, Anti-HBc and Anti-HBs antibodies).Results: The overall prevalence was 42.3% for antibody to hepatitis B core antigen, 15.5% for HBsAg of which 1.3% of HBsAg alone. HBV familial antecedents, sexual activity and socioeconomic conditions were the main risk factors of HBV infection encountered in the adolescents and young adults.Conclusion: These results show for the first time the high prevalence of HBV in apparently healthy young people in Bangui. This high prevalence is age- and sex-independent. Transmission risk factors were a familial antecedent of HBV, no utilisation of condoms and public scholarship. To lower HBV prevalence, an adequate program of active screening and vaccination for adolescents and young adults should be implemented, along with a universal immunization program. © 2010 Komas et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Komas, Narcisse Patrice Joseph
Central African Republic, Bangui
Institut Pasteur de Bangui
Baï-Sepou, Souleyman
Central African Republic, Bangui
Institut Pasteur de Bangui
Manirakiza, Alexandre
Central African Republic, Bangui
Institut Pasteur de Bangui
Léal, Josiane
Central African Republic, Bangui
Institut Pasteur de Bangui
Béré, Aubin
Central African Republic, Bangui
Institut Pasteur de Bangui
Le Faou, Alain E.
Central African Republic, Bangui
Institut Pasteur de Bangui
France, Vandoeouvre-les-nancy
Hôpital Brabois Adultes
Statistics
Citations: 85
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1186/1471-2334-10-226
e-ISSN:
14712334
Research Areas
Cancer
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Central African Republic