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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection
Nature Communications, Volume 1, No. 7, Article 102, Year 2010
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Description
HIV can be partially contained by host immunity and understanding the basis of this may inform vaccine design. The importance of B-cell function in long-term control is poorly understood. One method of investigating this is in vivo cellular depletion. In this study, we take advantage of a unique opportunity to investigate the role of B cells in an HIV-infected patient. The HIV-1+ patient studied here was not taking antiretroviral drugs and was treated for pre-existing low-grade lymphoplasmacytoid lymphoma by depletion of CD20+ B cells using rituximab. We demonstrate that B-cell depletion results in a decline in autologous neutralizing antibody (NAb) responses and a 1.7 log10 rise in HIV-1 plasma viral load (pVL). The recovery of NAbs results in a decline in pVL. The HIV-1 sequences diversify and NAb-resistant mutants are subsequently selected. These data suggest that B-cell function can contribute to the long-term control of pVL, and that NAbs may be more important in controlling chronic HIV-1 infection than previously suspected. © 2010 Macmillan Publishers Limited. All rights reserved.
Authors & Co-Authors
Huang, Kuan Hsiang Gary
United Kingdom, Oxford
Nuffield Department of Medicine
Bonsall, David G.
United Kingdom, London
Imperial College London
Katzourakis, Aris I.
United Kingdom, Oxford
University of Oxford
Thomson, Emma C.
United Kingdom, London
Imperial College London
Fidler, Sarah J.
United Kingdom, London
Imperial College London
Weber, Jonathan N.
United Kingdom, London
Imperial College London
Frater, John
United Kingdom, Oxford
Nuffield Department of Medicine
Phillips, Rodney E.
United Kingdom, Oxford
Nuffield Department of Medicine
Pybus, Oliver George
United Kingdom, Oxford
University of Oxford
Goulder, Philip Jeremy Renshaw
United Kingdom, Oxford
Nuffield Department of Medicine
McClure, Myra Olga
United Kingdom, London
Imperial College London
Cooke, Graham S.
United Kingdom, London
Imperial College London
Klenerman, Paul
United Kingdom, Oxford
Nuffield Department of Medicine
Statistics
Citations: 63
Authors: 13
Affiliations: 3
Identifiers
Doi:
10.1038/ncomms1100
ISSN:
20411723
Research Areas
Health System And Policy
Infectious Diseases