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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion
Nature, Volume 599, No. 7883, Year 2021
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Description
The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in the state of Maharashtra in late 2020 and spread throughout India, outcompeting pre-existing lineages including B.1.617.1 (Kappa) and B.1.1.7 (Alpha)1. In vitro, B.1.617.2 is sixfold less sensitive to serum neutralizing antibodies from recovered individuals, and eightfold less sensitive to vaccine-elicited antibodies, compared with wild-type Wuhan-1 bearing D614G. Serum neutralizing titres against B.1.617.2 were lower in ChAdOx1 vaccinees than in BNT162b2 vaccinees. B.1.617.2 spike pseudotyped viruses exhibited compromised sensitivity to monoclonal antibodies to the receptor-binding domain and the amino-terminal domain. B.1.617.2 demonstrated higher replication efficiency than B.1.1.7 in both airway organoid and human airway epithelial systems, associated with B.1.617.2 spike being in a predominantly cleaved state compared with B.1.1.7 spike. The B.1.617.2 spike protein was able to mediate highly efficient syncytium formation that was less sensitive to inhibition by neutralizing antibody, compared with that of wild-type spike. We also observed that B.1.617.2 had higher replication and spike-mediated entry than B.1.617.1, potentially explaining the B.1.617.2 dominance. In an analysis of more than 130 SARS-CoV-2-infected health care workers across three centres in India during a period of mixed lineage circulation, we observed reduced ChAdOx1 vaccine effectiveness against B.1.617.2 relative to non-B.1.617.2, with the caveat of possible residual confounding. Compromised vaccine efficacy against the highly fit and immune-evasive B.1.617.2 Delta variant warrants continued infection control measures in the post-vaccination era. © 2021, The Author(s).
Authors & Co-Authors
Mlčochová, Petra
United Kingdom, Cambridge
University of Cambridge
Kemp, Steven A.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, London
University College London
Papa, Guido
United Kingdom, Cambridge
The Medical Research Council Laboratory of Molecular Biology
Meng, Bo
United Kingdom, Cambridge
University of Cambridge
Ferreira, Isabella A.T.M.
United Kingdom, Cambridge
University of Cambridge
Datir, Rawlings P.
United Kingdom, Cambridge
University of Cambridge
Collier, Dami Aderonke
United Kingdom, Cambridge
University of Cambridge
United Kingdom, London
University College London
Albecka, Anna
United Kingdom, Cambridge
The Medical Research Council Laboratory of Molecular Biology
Singh, Sujeet Kumar
India, New Delhi
National Centre for Disease Control
Pandey, R. K.
India, New Delhi
Council of Scientific and Industrial Research India
Mishra, Swapnil
United Kingdom, London
Medical Research Council
Whittaker, Charles A.
United Kingdom, London
Medical Research Council
Mellan, Thomas A.
United Kingdom, London
Medical Research Council
Marwal, Robin
India, New Delhi
National Centre for Disease Control
Datta, Meena
India, New Delhi
National Centre for Disease Control
Sengupta, Shantanu
India, New Delhi
Council of Scientific and Industrial Research India
Ponnusamy, Kalaiarasan
India, New Delhi
National Centre for Disease Control
Venkatraman, Radhakrishnan Srinivasan
India, New Delhi
National Centre for Disease Control
Abdullahi, Adam
United Kingdom, Cambridge
University of Cambridge
Charles, Oscar J.
United Kingdom, London
University College London
Wattal, Chand
Unknown Affiliation
Vaishya, Raju
India, New Delhi
Indraprastha Apollo Hospitals
Dikid, Tanzin
India, New Delhi
National Centre for Disease Control
Gogia, Hema
India, New Delhi
National Centre for Disease Control
Lall, Hemlata
India, New Delhi
National Centre for Disease Control
Verma, Kaptan
India, New Delhi
National Centre for Disease Control
Singh, Manoj K.
India, New Delhi
National Centre for Disease Control
Soni, Namita
India, New Delhi
National Centre for Disease Control
Meena, Namonarayan
India, New Delhi
National Centre for Disease Control
Madan, Preeti
India, New Delhi
National Centre for Disease Control
Singh, Priyanka
India, New Delhi
National Centre for Disease Control
Sharma, Ramesh
India, New Delhi
National Centre for Disease Control
Sharma, Rajeev M.
India, New Delhi
National Centre for Disease Control
Kabra, Sandhya
India, New Delhi
National Centre for Disease Control
Kumar, Sattender
India, New Delhi
National Centre for Disease Control
Kumari, Swati
India, New Delhi
National Centre for Disease Control
Sharma, Uma
India, New Delhi
National Centre for Disease Control
Chaudhary, Urmila
India, New Delhi
National Centre for Disease Control
Sivasubbu, Sridhar
India, New Delhi
Council of Scientific and Industrial Research India
Oberoi, Jaswinder Kaur
Unknown Affiliation
Raveendran, Reena
Unknown Affiliation
Datta, Sanghamitra
Unknown Affiliation
Das, Saumitra M.
India, Kalyani
National Institute of Biomedical Genomics
Maitra, Arindam
India, Kalyani
National Institute of Biomedical Genomics
Chinnaswamy, Sreedhar
India, Kalyani
National Institute of Biomedical Genomics
Biswas, Nidhan K.
India, Kalyani
National Institute of Biomedical Genomics
Parida, Ajay Kumar
India, Bhubaneswar
Institute of Life Sciences India
Raghav, Sunil Kumar
India, Bhubaneswar
Institute of Life Sciences India
Prasad, Punit
India, Bhubaneswar
Institute of Life Sciences India
Sarin, Apurva
India, Bengaluru
National Centre for Biological Sciences
Mayor, Satyajit
India, Bengaluru
National Centre for Biological Sciences
Ramakrishnan, Uma
India, Bengaluru
National Centre for Biological Sciences
Palakodeti, Dasaradhi
India, Bengaluru
National Centre for Biological Sciences
Seshasayee, Aswin Sai Narain
India, Bengaluru
National Centre for Biological Sciences
Thangaraj, Kumarasamy
India, Hyderabad
Centre for Dna Fingerprinting and Diagnostics India
Bashyam, Murali Dharan
India, Hyderabad
Centre for Dna Fingerprinting and Diagnostics India
Dalal, Ashwin Bhikaji
India, Hyderabad
Centre for Dna Fingerprinting and Diagnostics India
Bhat, Manoj Kumar
India, Pune
National Centre for Cell Science India
Shouche, Yogesh Shreepad
India, Pune
National Centre for Cell Science India
Pillai, Ajay
India, Pune
National Centre for Cell Science India
Abraham, Priya S.
India, Pune
National Institute of Virology India
Potdar, Varsha Atul
India, Pune
National Institute of Virology India
Cherian, Sarah Sabu
India, Pune
National Institute of Virology India
Desai, Anita Sudhir
India, Bengaluru
National Institute of Mental Health and Neuro Sciences
Pattabiraman, Chitra
India, Bengaluru
National Institute of Mental Health and Neuro Sciences
Manjunatha, M. V.
India, Bengaluru
National Institute of Mental Health and Neuro Sciences
Mani, Reeta Subramaniam
India, Bengaluru
National Institute of Mental Health and Neuro Sciences
Udupi, Gautam Arunachal
India, Bengaluru
National Institute of Mental Health and Neuro Sciences
Nandicoori, Vinay Kumar
India, Hyderabad
Centre for Cellular and Molecular Biology India
Tallapaka, Karthik Bharadwaj
India, Hyderabad
Centre for Cellular and Molecular Biology India
Sowpati, Divya Tej
India, Hyderabad
Centre for Cellular and Molecular Biology India
Kawabata, Ryoko
Japan, Higashihiroshima
Hiroshima University
Morizako, Nanami
Japan, Higashihiroshima
Hiroshima University
Sadamasu, Kenji
Japan, Tokyo
Tokyo Metropolitan Institute of Public Health
Asakura, Hiroyuki
Japan, Tokyo
Tokyo Metropolitan Institute of Public Health
Nagashima, Mami
Japan, Tokyo
Tokyo Metropolitan Institute of Public Health
Yoshimura, Kazuhisa
Japan, Tokyo
Tokyo Metropolitan Institute of Public Health
Ito, Jumpei
Japan, Tokyo
The University of Tokyo
Kimura, Izumi
Japan, Tokyo
The University of Tokyo
Uriu, Keiya
Japan, Tokyo
The University of Tokyo
Kosugi, Yusuke
Japan, Tokyo
The University of Tokyo
Suganami, Mai
Japan, Tokyo
The University of Tokyo
Oide, Akiko
Japan, Tokyo
The University of Tokyo
Yokoyama, Miyabishara
Japan, Tokyo
The University of Tokyo
Chiba, Mika
Japan, Tokyo
The University of Tokyo
Saito, Akatsuki
Japan, Miyazaki
University of Miyazaki
Butlertanaka, Erika P.
Japan, Miyazaki
University of Miyazaki
Tanaka, Yuri L.
Japan, Miyazaki
University of Miyazaki
Ikeda, Terumasa
Japan, Kumamoto
Kumamoto University
Motozono, Chihiro
Japan, Kumamoto
Kumamoto University
Nasser, Hesham
Japan, Kumamoto
Kumamoto University
Shimizu, Ryo
Japan, Kumamoto
Kumamoto University
Yuan, Yue
Japan, Kumamoto
Kumamoto University
Kitazato, Kazuko
Japan, Kumamoto
Kumamoto University
Hasebe, Haruyo
Japan, Kumamoto
Kumamoto University
Nakagawa, So
Japan, Tokyo
Tokai University
Wu, Jiaqi
Japan, Tokyo
Tokai University
Takahashi, Miyoko
Japan, Tokyo
Tokai University
Fukuhara, Takasuke
Japan, Sapporo
Hokkaido University
Shimizu, Kenta
Japan, Sapporo
Hokkaido University
Tsushima, Kana
Japan, Sapporo
Hokkaido University
Kubo, Haruko
Japan, Sapporo
Hokkaido University
Shirakawa, Kotaro
Japan, Kyoto
Kyoto University
Kazuma, Yasuhiro
Japan, Kyoto
Kyoto University
Nomura, Ryosuke
Japan, Kyoto
Kyoto University
Horisawa, Yoshihito
Japan, Kyoto
Kyoto University
Takaori-Kondo, Akifumi
Japan, Kyoto
Kyoto University
Tokunaga, Kenzo
Japan, Tokyo
National Institute of Infectious Diseases
Ozono, Seiya
Japan, Tokyo
National Institute of Infectious Diseases
Baker, Stephen G.
United Kingdom, Cambridge
University of Cambridge
Dougan, Gordon J.
United Kingdom, Cambridge
University of Cambridge
Hess, Christoph
United Kingdom, Cambridge
University of Cambridge
Kingston, Nathalie
Unknown Affiliation
Lehner, P. Joseph
United Kingdom, Cambridge
University of Cambridge
Lyons, Paul A.
United Kingdom, Cambridge
University of Cambridge
Matheson, Nicholas J.
United Kingdom, Cambridge
University of Cambridge
Saunders, Caroline
United Kingdom, Oxford
University of Oxford
Summers, Charlotte
United Kingdom, Cambridge
University of Cambridge
Toshner, Mark R.
United Kingdom, Cambridge
University of Cambridge
Weekes, Michael P.
United Kingdom, Cambridge
University of Cambridge
Shaw, Ashley S.
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Bucke, Ashlea
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Calder, Jo
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Canna, Laura
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Domingo, Jason
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Elmer, Anne
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Harris, Julie
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Hewitt, Sarah
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Kennet, Jane
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Jose, Sherly
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Kourampa, Jenny
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Meadows, Anne
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Price, Jane
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Rastall, Rebecca J.
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Ribeiro, Carla G.
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Rowlands, Jane
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Tordesillas, Hugo
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Dunmore, Benjamin J.
United Kingdom, Cambridge
University of Cambridge
Huang, Christopher L.H.
India, New Delhi
National Centre for Disease Control
Mescia, Federica
United Kingdom, Cambridge
University of Cambridge
Bergamaschi, Laura
United Kingdom, Cambridge
University of Cambridge
Gleadall, Nicholas S.
United Kingdom, Cambridge
University of Cambridge
Huhn, Oisín
United Kingdom, Cambridge
University of Cambridge
Jarvis, Isobel
United Kingdom, Cambridge
University of Cambridge
Stephens, Jonathan Claiborne
South Africa, Durban
Africa Health Research Institute
Turner, Lori
United Kingdom, Cambridge
University of Cambridge
Dewhurst, Eleanor F.
United Kingdom, Cambridge
University of Cambridge
Papadia, Sofia
United Kingdom, Cambridge
University of Cambridge
Stirrups, Kathleen E.
South Africa, Durban
Africa Health Research Institute
Townsend, Paul A.
United Kingdom, Cambridge
University of Cambridge
Yoshida, Isao
Japan, Tokyo
Tokyo Metropolitan Institute of Public Health
Hamilton, William L.
United Kingdom, Cambridge
University of Cambridge
Sato, Kei
Japan, Tokyo
The University of Tokyo
Japan, Kawaguchi
Japan Science and Technology Agency
Bhatt, S. M.
India, New Delhi
National Centre for Disease Control
Denmark, Copenhagen
Københavns Universitet
Flaxman, Seth R.
United Kingdom, Oxford
University of Oxford
James, Leo C.
United Kingdom, Cambridge
The Medical Research Council Laboratory of Molecular Biology
Corti, Davide
United States, San Francisco
Vir Biotechnology, Inc.
Piccoli, Luca
United States, San Francisco
Vir Biotechnology, Inc.
Barclay, Wendy S.
United Kingdom, London
Medical Research Council
Rakshit, Partha
India, New Delhi
National Centre for Disease Control
Agrawal, Anurag
India, New Delhi
Council of Scientific and Industrial Research India
Gupta, Ravindra K.
United Kingdom, Cambridge
University of Cambridge
South Africa, Durban
Africa Health Research Institute
Statistics
Citations: 780
Authors: 162
Affiliations: 32
Identifiers
Doi:
10.1038/s41586-021-03944-y
ISSN:
00280836
Research Areas
Covid