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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Chromosome analyses of lymphoid cell lines derived from patients with chronic lymphocytic leukemia
International Journal of Cancer, Volume 26, No. 5, Year 1980
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Description
To study chromosome complements of chronic lymphocytic leukemia cells, six Epstein‐Barr virus‐transformed lymphoid lines were established from two patients with this disease who were heterozygous for the X‐chromosome‐linked enzyme glucose‐6‐phosphate de‐hydrogenase (G6PD). Immunoglobulin and G6PD were used as markers of the leukemic versus normal cell origin of the cell lines. The two lines, derived from putative normal cells, had no chromosomal changes. In contrast, chomosome abnormalities were found in each of the four cell lines of presumed leukemic cell origin. Although the chromosome aberrations are not as specific as the Philadelphia chromosome, there appears to be non‐random involvement in chronic lymphocytic leukemia of some chomosomes, such as the No. 12. Copyright © 1980 Wiley‐Liss, Inc., A Wiley Company
Authors & Co-Authors
Najfeld, Vesna
United States, Seattle
University of Washington
Fialkow, Phillip J.
United States, Seattle
University of Washington
Karande, A.
Sweden, Stockholm
Karolinska Institutet
Nilsson, K.
Sweden, Uppsala
Uppsala Universitet
Klein, George O.
Sweden, Stockholm
Karolinska Institutet
Penfold, Grace K.
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 40
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1002/ijc.2910260504
ISSN:
00207136
e-ISSN:
10970215
Research Areas
Genetics And Genomics