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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Compartmentalization of HIV-1 between breast milk and blood of HIV-infected mothers
Virology, Volume 300, No. 1, Year 2002
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Description
HIV-1 variants in breast milk and peripheral blood have been compared in three HIV-1 infected mothers. Analysis of DNA and RNA env C2-V3 sequences showed a differential distribution of HIV variants between the two compartments. The major provirus variant found in breast milk corresponds to a minor variant in the blood of two mothers. In the third mother, the predominant proviral variant detected in breast milk was not represented in the HIV-1 blood population. The major RNA variant in breast milk was not represented in the blood of two mothers. The predominant RNA variant in breast milk and blood was however the same for the third mother. Unexpectedly, the pattern of free virus variants in breast milk of three mothers did not correspond to that of the proviral form, suggesting that free viruses do not derive from infected cells in breast milk. The observation of a compartmentalization of HIV-1 between peripheral blood and breast milk emphasizes that postnatal transmission of HIV occurs with variants that may not be predicted from the analysis of circulating viral populations. © 2002 Elsevier Science (USA).
Authors & Co-Authors
Becquart, Pierre
France, Paris
Hopital Broussais
Chomont, Nicolas
France, Paris
Hopital Broussais
Roques, Pierre A.
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
France, Fontenay-aux-roses
Cea Fontenay Aux Roses
Ayouba, Ahidjo
France, Paris
Centre Pasteur du Cameroun
Kazatchkine, Michel Daniel
France, Paris
Hopital Broussais
France, Paris
Sorbonne Université
Bélec, Laurent
France, Paris
Hopital Broussais
France, Paris
Sorbonne Université
Hocini, Hakim
France, Paris
Hopital Broussais
Statistics
Citations: 81
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1006/viro.2002.1537
ISSN:
00426822
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study