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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A randomized, double-blind comparison between parecoxib sodium and propacetamol for parenteral postoperative analgesia after inguinal hernia repair in adult patients
Anesthesia and Analgesia, Volume 100, No. 5, Year 2005
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Description
The newly injectable cyclooxygenase-2 selective nonsteroidal antiinflammatory drug, parecoxib, has never been compared with propacetamol, a parenteral formulation of acetaminophen. In this prospective, randomized, double-blind, double-dummy study, we randomly assigned 182 patients scheduled for initial inguinal hernia repair under general anesthesia to receive a single injection of 40 mg parecoxib or 2 injections of 2 g propacetamol within the first 12 h after surgery. The study variables were morphine consumption, pain at rest and while coughing, and patient satisfaction throughout the first 12 h postoperatively. For statistical analysis, we used the Student's t-test, χ2, and covariance analysis. Total morphine consumption did not differ between the two groups. Pain was less intense in the parecoxib group at rest (P = 0.035) but did not differ for pain while coughing. The incidence of side effects was similar. Significantly more patients in the parecoxib group rated their pain management as good or excellent (87% versus 70% in the propacetamol group, P = 0.001). Within the first 12 h after inguinal hernia repair in adult patients, a single injection of parecoxib 40 mg compares favorably with 2 injections of propacetamol 2 g. ©2005 by the International Anesthesia Research Society.
Authors & Co-Authors
Beaussier, M.
France, Paris
Hôpital Saint-antoine
Weickmans, H.
France, Paris
Hôpital Saint-antoine
Paugam, C.
France, Paris
Hôpital Saint-antoine
Lavazais, S.
France, Poitiers
Centre Hospitalier Universitaire de Poitiers
Baechle, J. P.
France, Lyon
Clinique de la Sauvegarde
Goater, P.
France, Paris
Hopital D'instruction Des Armées du Val de Grace
Buffin, A.
France, Metz
Chu Annecy
Loriferne, J. F.
France
Hopital Ste Camille
Perier, J. F.
France, Paris
Hôpital Tenon
Didelot, J. P.
France, Vandoeouvre-les-nancy
Hôpital Brabois Adultes
Mosbah, A. F.
Tunisia, Sousse
Chu Sahloul
Saïd, Rachid
Tunisia, Sousse
Chu Sahloul
Lienhart, A.
France, Paris
Hôpital Saint-antoine
Statistics
Citations: 34
Authors: 13
Affiliations: 9
Identifiers
Doi:
10.1213/01.ANE.0000150972.88708.13
ISSN:
00032999
Research Areas
Disability
Health System And Policy
Study Design
Cohort Study
Study Approach
Quantitative