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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content
British Journal of Nutrition, Volume 109, No. 10, Year 2013
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Description
SCFA are produced in the gut by bacterial fermentation of undigested carbohydrates. Activation of the Gαi-protein-coupled receptor GPR41 by SCFA in β-cells and sympathetic ganglia inhibits insulin secretion and increases sympathetic outflow, respectively. A possible role in stimulating leptin secretion by adipocytes is disputed. In the present study, we investigated energy balance and glucose homoeostasis in GPR41 knockout mice fed on a standard low-fat or a high-fat diet. When fed on the low-fat diet, body fat mass was raised and glucose tolerance was impaired in male but not female knockout mice compared to wild-type mice. Soleus muscle and heart weights were reduced in the male mice, but total body lean mass was unchanged. When fed on the high-fat diet, body fat mass was raised in male but not female GPR41 knockout mice, but by no more in the males than when they were fed on the low-fat diet. Body lean mass and energy expenditure were reduced in male mice but not in female knockout mice. These results suggest that the absence of GPR41 increases body fat content in male mice. Gut-derived SCFA may raise energy expenditure and help to protect against obesity by activating GPR41. © 2012 The Authors.
Authors & Co-Authors
Bellahcene, Mohamed
Unknown Affiliation
O'Dowd, Jacqueline F.
Unknown Affiliation
Wargent, Edward T.
Unknown Affiliation
Zaibi, Mohamed S.
Unknown Affiliation
Hislop, David C.
Unknown Affiliation
Ngala, Robert Amadu
Unknown Affiliation
Smith, David M.
Unknown Affiliation
Cawthorne, Michael Anthony
Unknown Affiliation
Stocker, Claire J.
Unknown Affiliation
Arch, Jonathan R.S.
Unknown Affiliation
Statistics
Citations: 116
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1017/S0007114512003923
ISSN:
00071145
e-ISSN:
14752662
Research Areas
Noncommunicable Diseases
Participants Gender
Male
Female