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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Age-related and infection intensity-related shifts in antibody recognition of defined protein antigens in a schistosome-exposed population
Journal of Infectious Diseases, Volume 198, No. 2, Year 2008
Notification
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Description
Background. This study compared patterns of recognition of defined Schistosoma haematobium adult worm antigens by serum antibodies from schistosome-exposed Zimbabweans aged 5-18 years. Methods. The population was stratified by age and infection intensity into 9 groups within which serum specimens were pooled and used to screen for protein recognition by 2-dimensional Western blotting. Recognized proteins were identified by electrospray ionizing tandem mass spectrometry. Results. A total of 71 antigens were recognized by ≥1 of the serum pools. The recognition varied distinctly with host age and infection intensity, with some isoform-specific responses. The repertoire of antigens recognized increased with age, peaking in the oldest participants whose had no or mild-to-moderate infection intensity. The intensity of antigen recognition also increased with age, peaking in the oldest participants with the heaviest infection intensity. Conclusions. The recognition of specific schistosome antigens, both in terms of the diversity of antigens recognized and the intensity of antigen recognition, increased with duration of exposure to infection, supporting the hypothesis that the slow development of schistosome-acquired immunity is due to the slow accumulation of responsiveness to relevant parasite antigens. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Mutapi, Francisca
Unknown Affiliation
Burchmore, Richard J.
Unknown Affiliation
Mduluza, Takafira
Unknown Affiliation
Midzi, Nicholas
Unknown Affiliation
Turner, Charles Michael R.
Unknown Affiliation
Maizels, Rick M.
Unknown Affiliation
Statistics
Citations: 62
Authors: 6
Affiliations: 6
Identifiers
Doi:
10.1086/589511
ISSN:
00221899
Study Design
Cross Sectional Study