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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Failure of fertilization in in vitro fertilization: The "Occult" male factor
Journal of In Vitro Fertilization and Embryo Transfer, Volume 5, No. 4, Year 1988
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Description
Failure of fertilization in patients undergoing in vitro fertilization (IVF) deserves extensive analysis for better prediction of the success or failure of this therapeutic modality. Consequently, we retrospectively studied the 52 couples in whom fertilization failed during Norfolk series 18 to 25, in an effort to establish the precise causes of failure. In the initial evaluation, pure oocyte abnormalities were identified in 19.2% of the cases; 32.6% showed sperm abnormalities, and a combination of oocyte and sperm anomalies was found in 7.7%. In 40.4% of the cases, failure of fertilization could not be explained. Re-assessment of sperm morphology by new, strict criteria increased the identification of sperm abnormalities to 61.5% and of combined sperm and oocyte anomalies to 13.4%, for a total of 74.9% of sperm factors involved, as opposed to 40.3% in the original evaluation. The incidence of unexplained failed fertilization was substantially reduced, to 11.5%. In a control group (tubal infertility) matched by age, date, and stimulation, in whom fertilization occurred, 83.3% had normal sperm parameters as judged by the new criteria for morphology evaluation. This paper emphasizes the need for a more accurate diagnosis of sperm abnormalities to establish the true incidence of this factor in failed fertilization and to obtain information of prognostic value to patients and clinicians. © 1988 Plenum Publishing Corporation.
Authors & Co-Authors
Oehninger, Sergio Carlos
United States, Norfolk
Eastern Virginia Medical School
Acosta, Aníbal A.
United States, Norfolk
Eastern Virginia Medical School
Kruger, Theunis Frans
United States, Norfolk
Eastern Virginia Medical School
South Africa, Tygerberg
Tygerberg Hospital
Veeck, Lucinda L.
United States, Norfolk
Eastern Virginia Medical School
Flood, Jill
United States, Norfolk
Eastern Virginia Medical School
Jones, Howard Walter
United States, Norfolk
Eastern Virginia Medical School
Statistics
Citations: 25
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1007/BF01131119
ISSN:
07407769
Research Areas
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Cohort Study
Participants Gender
Male