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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
environmental science
Beneficial effect of astaxanthin on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury in rats
Toxicology and Industrial Health, Volume 29, No. 7, Year 2013
Notification
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Description
Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) represents a potential health risk and hepatotoxicity. Astaxanthin (ASTA) exhibits antioxidant properties and can influence hepatotoxicity. Therefore, the present study was carried out for using ASTA against hepatotoxicity induced by TCDD in the liver of rats. Animals were treated intraperitoneally daily with TCDD (8 µg/kg body weight (b.w.)), ASTA (12.5 mg/kg b.w. and 25 mg/kg b.w.) and TCDD plus ASTA (12.5 and 25 mg/kg b.w.) for 21 days. TCDD significantly decreased the activities of antioxidant enzymes and resulted in serious pathological findings. Moreover, the rate of micronucleus (MN) in hepatocytes increased after treating with TCDD. The activities of enzymes, frequencies of MNs and liver histology in lower dosage group of ASTA remained unchanged compared with the control group. In rats treated with ASTA, at higher dosage alone, the MNs remained unchanged and the activities of antioxidant enzymes significantly increased. The presence of ASTA (except for lower dose) with TCDD alleviated its pathological effects in hepatic tissue. ASTA also prevented the suppression of antioxidant enzymes in the livers of animals exposed to TCDD and displayed a strong protective effect against MNs. Thus, the present findings might provide new insight into the development of therapeutic and preventive approaches of TCDD toxicity. © 2012, SAGE Publications. All rights reserved.
Authors & Co-Authors
Türkez, Hasan
Turkey, Erzurum
Erzurum Teknik Üniversitesi
Geyikoğlu, Fatime
Turkey, Erzurum
Atatürk Üniversitesi
Yousef, M. I.
Egypt, Alexandria
Institute of Graduate Studies and Research
Statistics
Citations: 28
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1177/0748233711434959
ISSN:
07482337
e-ISSN:
14770393
Research Areas
Violence And Injury
Study Design
Randomised Control Trial