Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Diagnostic accuracy of S100B urinary testing at birth in full-term asphyxiated newborns to predict neonatal death
PLoS ONE, Volume 4, No. 2, Article e4298, Year 2009
Notification
URL copied to clipboard!
Description
Background: Neonatal death in full-term infants who suffer from perinatal asphyxia (PA) is a major subject of investigation, since few tools exist to predict patients at risk of ominous outcome. We studied the possibility that urine S100B measurement may identify which PA-affected infants are at risk of early postnatal death. Methodology/Principal Findings: In a cross-sectional study between January 1, 2001 and December 1, 2006 we measured S100B protein in urine collected from term infants (n = 132), 60 of whom suffered PA. According to their outcome at 7 days, infants with PA were subsequently classified either as asphyxiated infants complicated by hypoxic ischemic encephalopathy with no ominous outcome (HIE Group; n = 48), or as newborns who died within the first post-natal week (Ominous Outcome Group; n = 12). Routine laboratory variables, cerebral ultrasound, neurological patterns and urine concentrations of S100B protein were determined at first urination and after 24, 48 and 96 hours. The severity of illness in the first 24 hours after birth was measured using the Score for Neonatal Acute Physiology-Perinatal Extension (SNAP-PE). Urine S100B levels were higher from the first urination in the ominous outcome group than in healthy or HIE Groups (p<0.001 for all), and progressively increased. Multiple logistic regression analysis showed a significant correlation between S100B concentrations and the occurrence of neonatal death. At a cut-off >1.0 μg/L S100B had a sensitivity/ specificity of 100% for predicting neonatal death. Conclusions/Significance: Increased S100B protein urine levels in term newborns suffering PA seem to suggest a higher risk of neonatal death for these infants. © 2009 Gazzolo et al.
Authors & Co-Authors
Gazzolo, Diego
Italy, Genoa
Istituto Giannina Gaslini
Italy, Catania
Ospedale Garibaldi
Frigiola, Alessandro
Italy, San Donato Milanese
Gruppo Ospedaliero San Donato
Bashir, Moataza
Egypt, Giza
Cairo University
Iskander, Iman Fathi
Egypt, Giza
Cairo University
Mufeed, Hala
Egypt, Giza
Cairo University
Aboulgar, Hanna
Egypt, Giza
Cairo University
Venturini, Pier Luigi
Italy, Genoa
Istituto Giannina Gaslini
Marras, Mauro
Italy, Genoa
Istituto Giannina Gaslini
Serra, Giovanni S.
Italy, Genoa
Istituto Giannina Gaslini
Frulio, Rosanna
Italy, Genoa
Istituto Giannina Gaslini
Michetti, Fabrizio
Italy, Rome
Università Cattolica Del Sacro Cuore, Campus Di Roma
Petraglia, Felice
Italy, Siena
Università Degli Studi Di Siena
Abella, Raúl Felipe
Italy, San Donato Milanese
Gruppo Ospedaliero San Donato
Florio, Pasquale
Italy, Siena
Università Degli Studi Di Siena
Statistics
Citations: 70
Authors: 14
Affiliations: 6
Identifiers
Doi:
10.1371/journal.pone.0004298
e-ISSN:
19326203
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative