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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Rotavirus and norovirus infections among acute gastroenteritis children in Morocco
BMC Infectious Diseases, Volume 14, No. 1, Article 300, Year 2014
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Description
Background: Acute gastroenteritis is a serious cause of child mortality and morbidity in resource-limited countries. A viral etiology is most common, and rotavirus and norovirus are reported to be the leading causative agents. There are still few epidemiological data on the simultaneous occurrence of these viruses in Morocco. The aim of this study was to provide useful epidemiological data on the gastroenteritis associated with rotavirus and norovirus among children aged less than 5 years.Methods: From January to December 2011, 335 samples were tested for rotavirus and norovirus using enzyme-linked immunosorbent assay, reverse-transcription-polymerase chain reaction (RT-multiplex PCR) and real-time RT-PCR. Partial sequences of the norovirus were phylogenetically analyzed to determine the genotype.Results: The overall rates of rotavirus and norovirus infections were 26.6% and 16.1%, respectively. Mixed viral infections were detected in 9 of 335 stool specimens (2.7%).The most common genotype combination in the rotavirus strains was G1[P8] (51.7%), followed by G2[P4] (10.1%), G2[P8] (4.5%), G9[P8] (3.4%), G4[P8] (3.4%), and G1[P6] (2.3%). Among patients positive for norovirus, 42 (77.8%) tested positive for GII and 12 (22.2%) for GI. Thirty-three (78.6%) of the norovirus GII-positive cases were successfully characterized. Genotype GII.4 was the most prevalent (n = 27; 81.8%), followed by GII.3 (n = 2; 6.1%), GII.13 (n = 2; 6.1%), GII.16 (n = 1; 3%), and GII.17 (n = 1; 3%).Conclusion: This study suggests that in Morocco, norovirus is the most frequent cause of acute gastroenteritis after rotavirus, but further enteric viruses need to be integrated in the surveillance system so that a conclusion could be drawn. © 2014 El Qazoui et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Elqazoui, Maria
Morocco, Agdal Rabat
Institut National D'hygiène
Oumzil, Hicham
Morocco, Agdal Rabat
Institut National D'hygiène
Baassi, Larbii
Morocco, Agdal Rabat
Institut National D'hygiène
El Omari, Nezha
Morocco, Agdal Rabat
Institut National D'hygiène
Sadki, Khalid
Morocco, Rabat
Faculté Des Sciences Rabat
Amzazi, Saaid
Morocco, Rabat
Faculté Des Sciences Rabat
Benhafid, Mohammed
Morocco, Agdal Rabat
Institut National D'hygiène
El Aouad, Rajae
Morocco, Rabat
Mohammed V University in Rabat
Statistics
Citations: 46
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1186/1471-2334-14-300
e-ISSN:
14712334
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Locations
Morocco