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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Prevalence and correlates of helminth co-infection in kenyan HIV-1 infected adults
PLoS Neglected Tropical Diseases, Volume 4, No. 3, Article e644, Year 2010
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Description
Background: Deworming HIV-1 infected individuals may delay HIV-1 disease progression. It is important to determine the prevalence and correlates of HIV-1/helminth co-infection in helminth-endemic areas. Methods: HIV-1 infected individuals (CD4>250 cells/ul) were screened for helminth infection at ten sites in Kenya. Prevalence and correlates of helminth infection were determined. A subset of individuals with soil-transmitted helminth infection was re-evaluated 12 weeks following albendazole therapy. Results: Of 1,541 HIV-1 seropositive individuals screened, 298 (19.3%) had detectable helminth infections. Among individuals with helminth infection, hookworm species were the most prevalent (56.3%), followed by Ascaris lumbricoides (17.1%), Trichuris trichiura (8.7%), Schistosoma mansoni (7.1%), and Stongyloides stercoralis (1.3%). Infection with multiple species occurred in 9.4% of infections. After CD4 count was controlled for, rural residence (RR 1.40, 95% CI: 1.08-1.81), having no education (RR 1.57, 95% CI: 1.07-2.30), and higher CD4 count (RR 1.36, 95% CI: 1.07-1.73) remained independently associated with risk of helminth infection. Twelve weeks following treatment with albendazole, 32% of helminth-infected individuals had detectable helminths on examination. Residence, education, and CD4 count were not associated with persistent helminth infection. Conclusions: Among HIV-1 seropositive adults with CD4 counts above 250 cells/mm3 in Kenya, traditional risk factors for helminth infection, including rural residence and lack of education, were associated with co-infection, while lower CD4 counts were not. Trial Registration: ClinicalTrials.gov NCT00130910. © 2010 Walson et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2846937/bin/pntd.0000644.s001.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2846937/bin/pntd.0000644.s002.pdf
Authors & Co-Authors
Walson, Judd L.
United States, Seattle
University of Washington
Stewart, Barclay T.
United States, Charleston
Medical University of South Carolina
Sangaré, Laura R.
United States, Seattle
University of Washington
Mbogo, Loice Wangari
Kenya, Nairobi
Kenya Medical Research Institute
Otieno, Phelgona Apondi O.
Kenya, Nairobi
Kenya Medical Research Institute
Piper, Benjamin K.S.
United States, Seattle
University of Washington
Kenya, Nairobi
Kenya Medical Research Institute
Richardson, Barbra Ann
United States, Seattle
University of Washington
John-Stewart, Grace C.
United States, Seattle
University of Washington
Statistics
Citations: 54
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1371/journal.pntd.0000644
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Kenya