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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Impact of maternal malaria and under-nutrition on intrauterine growth restriction: A prospective ultrasound study in Democratic Republic of Congo
Epidemiology and Infection, Volume 137, No. 2, Year 2009
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Description
Maternal malaria and under-nutrition are established risk factors for small-for-gestational-age (SGA) births; however, whether malaria is associated with intrauterine growth restriction (IUGR) is unknown. We investigated IUGR risk among 177 HIV-negative pregnant women enrolled in a longitudinal ultrasound study conducted in Democratic Republic of Congo from May 2005 to May 2006. Malaria infection, maternal anthropometrics, and ultrasound estimated fetal weight were measured monthly. All positive malaria cases were treated and intermittent presumptive therapy (IPTp) provided. Log-binomial regression models for IUGR were fitted using generalized estimating equations to account for statistical clustering of repeat IUGR measurements. Twenty-nine percent of fetuses experienced an episode of IUGR with the majority occurring in the third trimester. The risk of IUGR associated with malaria was greatest after three or more cumulative infections (RR 3.3, 95% CI 1.3-8.2) and was two- to eight-fold higher among women with evidence of under-nutrition. Receiving antimalarial treatment in the previous month (for IPTp or treatment) was significantly protective against IUGR (RR 0.5, 95% CI 0.3-0.7). The interaction observed between malaria and under-nutrition suggests that antenatal programmes in malaria endemic areas should incorporate nutritional screening and supplementation in addition to IPTp. © 2008 Cambridge University Press.
Authors & Co-Authors
Landis, Sarah H.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Lokomba, Victor
Congo
Unc-drc Programme
Ananth, Cande V.
United States, New Brunswick
Rutgers Robert Wood Johnson Medical School at new Brunswick
Atibu, Joseph
Congo
Unc-drc Programme
Ryder, Robert W.
United States, La Jolla
University of California, San Diego
Hartmann, Katherine E.
United States, Nashville
Vanderbilt University Medical Center
Thorp, John M.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Tshefu, Antoinette Kitoto
Congo
Unc-drc Programme
Meshnick, Steven Richard
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Statistics
Citations: 70
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1017/S0950268808000915
ISSN:
09502688
e-ISSN:
14694409
Research Areas
Food Security
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Congo
Participants Gender
Female