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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Modulation of LPS-induced CD4+ T-cell activation and apoptosis by antioxidants in untreated asymptomatic HIV infected participants: An in vitro study
Clinical and Developmental Immunology, Volume 2013, Article 631063, Year 2013
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Description
Persistent immune activation characterises HIV infection and is associated with depletion of CD4+ T-cells and increased risk of disease progression. Early loss of gut mucosal integrity results in the translocation of microbial products such as lipopolysaccharide (LPS) into the systemic circulation. This is an important source of on-going immune stimulation. The purpose of this study was to determine levels of CD4+ T-cell activation (%CD25 expression) and apoptosis (% annexin V/7-AAD) in asymptomatic, untreated HIV infection at baseline and after stimulation with LPS and incubation with or without vitamin C and N-acetylcysteine. LPS induced a significant (P<0.03) increase in %CD25 expression, annexin V, and 7-AAD in HIV positive individuals. NAC in combination with vitamin C, significantly (P=0.0018) reduced activation and early apoptosis of CD4+ T-cells to a greater degree than with either antioxidant alone. Certain combinations of antioxidants could be important in reducing the harmful effects of chronic immune activation and thereby limit CD4+ T-cell depletion. Importantly, we showed that CD4+ T-cells of the HIV positive group responded better to a combination of the antioxidants at this stage than those of the controls. Therefore, appropriate intervention at this asymptomatic stage could rescue the cells before repetitive activation results in the death of CD4+ T-cells. © 2013 S. Mburu et al.
Authors & Co-Authors
Mburu, S.
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Marnewick, Jeanine L.
South Africa, Bellville
Cape Peninsula University of Technology
Abayomi, Emmanuel Akinola
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Ipp, Hayley
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Statistics
Citations: 20
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1155/2013/631063
ISSN:
17402522
Research Areas
Cancer
Infectious Diseases
Study Design
Randomised Control Trial