Publication Details

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Predictive value of interferon-lambda gene polymorphisms for treatment response in chronic hepatitis C

PLoS ONE, Volume 9, No. 11, Article e112592, Year 2014

Background: IL28B gene polymorphism is the best baseline predictor of response to interferon alfa-based antiviral therapies in chronic hepatitis C. Recently, a new IFN-L4 polymorphism was identified as first potential functional variant for induction of IL28B expression. Individualization of interferon alfa-based therapies based on a combination of IL28B/IFN-L4 polymorphisms may help to optimize virologic outcome and economic resources. Copyright:

Statistics
Citations: 25
Authors: 9
Affiliations: 3
Identifiers
Doi: 10.1371/journal.pone.0112592
e-ISSN: 19326203
Research Areas
Genetics And Genomics
Infectious Diseases

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