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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
psychology
Harmonizing PTSD Severity Scales Across Instruments and Sites
Neuropsychology, Volume 37, No. 4, Year 2022
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Description
Objective: The variety of instruments used to assess posttraumatic stress disorder (PTSD) allows for flexibility, but also creates challenges for data synthesis. The objective of this work was to use a multisite mega analysis to derive quantitative recommendations for equating scores across measures of PTSD severity. Method: Empirical Bayes harmonization and linear models were used to describe and mitigate site and covariate effects. Quadratic models for converting scores across PTSD assessments were constructed using bootstrapping and tested on hold out data. Results: We aggregated 17 data sources and compiled an n = 5,634 sample of individuals who were assessed for PTSD symptoms. We confirmed our hypothesis that harmonization and covariate adjustments would significantly improve inference of scores across instruments. Harmonization significantly reduced cross-dataset variance (28%, p <.001), and models for converting scores across instruments were well fit (median R2 = 0.985) with an average root mean squared error of 1.46 on sum scores. Conclusions: These methods allow PTSD symptom severity to be placed on multiple scales and offers interesting empirical perspectives on the role of harmonization in the behavioral sciences. © 2022 American Psychological Association
Authors & Co-Authors
Kennedy, Eamonn
United States, Salt Lake City
University of Utah School of Medicine
United States
Va Medical Center
United States, Salt Lake City
The University of Utah
Dennis, Emily L.
United States, Salt Lake City
University of Utah School of Medicine
United States
Va Medical Center
Lindsey, Hannah M.
United States, Salt Lake City
University of Utah School of Medicine
United States
Va Medical Center
DeRoon-Cassini, Terri A.
United States, Milwaukee
Medical College of Wisconsin
Du Plessis, Stéfan
South Africa, Cape Town
University of Cape Town
South Africa, Cape Town
Sa Mrc Unit on Risk and Resilience in Mental Disorders
Fani, Negar
United States, Atlanta
Emory University School of Medicine
Kaufman, Milissa L.
United States, Boston
Harvard Medical School
United States, Belmont
Mclean Hospital
Koen, Nastassja
South Africa, Cape Town
University of Cape Town
South Africa, Cape Town
Sa Mrc Unit on Risk and Resilience in Mental Disorders
Larson, Christine L.
United States, Milwaukee
University of Wisconsin-milwaukee
Laskowitz, Sarah
United States, Durham
Brain Imaging and Analysis Center
Lebois, Lauren A.M.
United States, Boston
Harvard Medical School
United States, Belmont
Mclean Hospital
Morey, Rajendra A.
United States, Durham
Brain Imaging and Analysis Center
United States, Durham
Durham V.a. Medical Center
Newsome, Mary R.
United States, Houston
Baylor College of Medicine
United States, Houston
Michael E. Debakey va Medical Center
Palermo, Cori A.
United States, Boston
Harvard Medical School
United States, Belmont
Mclean Hospital
Pastorek, Nicholas J.
United States, Houston
Baylor College of Medicine
United States, Houston
Michael E. Debakey va Medical Center
Powers, Abigail D.
United States, Atlanta
Emory University School of Medicine
Scheibel, Randall S.
United States, Houston
Baylor College of Medicine
United States, Houston
Michael E. Debakey va Medical Center
Seedat, Soraya
South Africa, Stellenbosch
Stellenbosch University
Seligowski, Antonia V.
United States, Boston
Harvard Medical School
United States, Belmont
Mclean Hospital
Stein, Dan J.
South Africa, Cape Town
University of Cape Town
South Africa, Cape Town
Sa Mrc Unit on Risk and Resilience in Mental Disorders
Sun, Delin
United States, Durham
Brain Imaging and Analysis Center
United States, Durham
Durham V.a. Medical Center
Thompson, Paul M.
United States, Los Angeles
Keck School of Medicine of Usc
Troyanskaya, Maya
United States, Houston
Baylor College of Medicine
United States, Houston
Michael E. Debakey va Medical Center
Van Rooij, Sanne J.H.
United States, Atlanta
Emory University School of Medicine
Watts, Amanda A.
United States, Durham
Brain Imaging and Analysis Center
Tomas, Carissa W.
United States, Milwaukee
Medical College of Wisconsin
Williams, Wright
United States, Houston
Michael E. Debakey va Medical Center
Hillary, Frank Gerard
United States, Hershey
Penn State Health Milton S. Hershey Medical Center
United States, University Park
Pennsylvania State University
Pugh, Mary Jo
United States, Salt Lake City
University of Utah School of Medicine
United States
Va Medical Center
United States, Salt Lake City
The University of Utah
Wilde, Elisabeth A.
United States, Salt Lake City
University of Utah School of Medicine
United States
Va Medical Center
United States, Houston
Baylor College of Medicine
Tate, David F.
United States, Salt Lake City
University of Utah School of Medicine
United States
Va Medical Center
Statistics
Citations: 5
Authors: 31
Affiliations: 18
Identifiers
Doi:
10.1037/neu0000823
ISSN:
08944105
Research Areas
Mental Health
Study Approach
Quantitative
Systematic review