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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Development of an ELISA detecting Tumor Protein 53-Induced Nuclear Protein 1 in serum of prostate cancer patients
Results in Immunology, Volume 3, Year 2013
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Description
Tumor Protein 53-Induced Nuclear Protein 1 (TP53INP1) plays an important role during cell stress response in synergy with the potent " genome-keeper" p53. In human, the gene encoding TP53INP1 is expressed at very high level in some pathological situations, such as inflammation and prostate cancer (PC). TP53INP1 overexpression in PC seems to be a worse prognostic factor, particularly predictive of biological cancer relapse, making TP53INP1 a relevant specific target for molecular therapy of Castration Resistant (CR) PC. In that context, detection of TP53INP1 in patient biological fluids is a promising diagnostic avenue. We report here successful development of a new Enzyme-Linked Immunosorbent Assay (ELISA) detecting TP53INP1, taking advantage of molecular tools (monoclonal antibodies (mAbs) and recombinant proteins) generated in the laboratory during the course of basic functional investigations devoted to TP53INP1. The ELISA principle is based on a sandwich immunoenzymatic system, TP53INP1 protein being trapped by a first specific mAb coated on microplate then recognized by a second specific mAb. This new assay allows specific detection of TP53INP1 in serum of several PC patients. This breakthrough paves the way towards investigation of a large cohort of patients and assessment of clinical applications of TP53INP1 dosage. © 2013 Elsevier B.V.
Authors & Co-Authors
Saadi, Houda
France, Marseille
Centre de Recherche en Cancérologie de Marseille
France, Marseille
Institut Paoli-calmettes
France, Marseille
Aix Marseille Université
France, Paris
Cnrs Centre National de la Recherche Scientifique
Tunisia, Tunis
Unité de Recherches no 01/ur/08-07
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Seillier, Marion
France, Marseille
Centre de Recherche en Cancérologie de Marseille
France, Marseille
Institut Paoli-calmettes
France, Marseille
Aix Marseille Université
France, Paris
Cnrs Centre National de la Recherche Scientifique
Sandi, Maria José
France, Marseille
Centre de Recherche en Cancérologie de Marseille
France, Marseille
Institut Paoli-calmettes
France, Marseille
Aix Marseille Université
France, Paris
Cnrs Centre National de la Recherche Scientifique
Peuget, Sylvain
France, Marseille
Centre de Recherche en Cancérologie de Marseille
France, Marseille
Institut Paoli-calmettes
France, Marseille
Aix Marseille Université
France, Paris
Cnrs Centre National de la Recherche Scientifique
Kellenberger, Christine
France, Marseille
Aix Marseille Université
France, Marseille
Laboratoire Architecture et Fonction Des Macromolécules Biologiques
Gravis, Gwénaëlle
France, Marseille
Institut Paoli-calmettes
Dusetti, Nelson J.
France, Marseille
Centre de Recherche en Cancérologie de Marseille
France, Marseille
Institut Paoli-calmettes
France, Marseille
Aix Marseille Université
France, Paris
Cnrs Centre National de la Recherche Scientifique
Iovanna, Juan Lucio
France, Marseille
Centre de Recherche en Cancérologie de Marseille
France, Marseille
Institut Paoli-calmettes
France, Marseille
Aix Marseille Université
France, Paris
Cnrs Centre National de la Recherche Scientifique
Rocchi, Palma
France, Marseille
Centre de Recherche en Cancérologie de Marseille
France, Marseille
Institut Paoli-calmettes
France, Marseille
Aix Marseille Université
France, Paris
Cnrs Centre National de la Recherche Scientifique
Amri, Mohamed A.
France, Marseille
Aix Marseille Université
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Carrier, Alice
France, Marseille
Centre de Recherche en Cancérologie de Marseille
France, Marseille
Institut Paoli-calmettes
France, Marseille
Aix Marseille Université
France, Paris
Cnrs Centre National de la Recherche Scientifique
Statistics
Citations: 11
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1016/j.rinim.2013.05.002
e-ISSN:
22112839
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Study Design
Cohort Study