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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Human bocaviruses are highly diverse, dispersed, recombination prone, and prevalent in enteric infections
Journal of Infectious Diseases, Volume 201, No. 11, Year 2010
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Description
A new species of parvovirus, tentatively named human bocavirus 4 (HBoV4), was genetically characterized. Among 641 feces samples obtained from children and adults, the most commonly detected bocavirus species were, in descending order, HBoV2, HBoV3, HBoV4, and HBoV1, with an HBoV2 prevalence of 21% and 26% in Nigerian and Tunisian children, respectively. HBoV3 or HBoV4 species were found in 12 of 192 patients with non-polio acute flaccid paralysis in Tunisia and Nigeria and 0 of 96 healthy Tunisian contacts (P = .01). Evidence of extensive recombination at the NP1 and VP1 gene boundary between and within bocavirus species was found. The high degree of genetic diversity seen among the human bocaviruses found in feces specimens, relative to the highly homogeneous HBoV1, suggest that this worldwide-distributed respiratory pathogen may have recently evolved from an enteric bocavirus after acquiring an expanded tropism favoring the respiratory tract. Elucidating the possible role of the newly identified enteric bocaviruses in human diseases, including acute flaccid paralysis and diarrhea, will require further epidemiological studies. © 2010 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Kapoor, Amit
United States, San Francisco
Ucsf School of Medicine
United States, San Francisco
Vitalant Research Institute
Simmonds, Peter N.
United Kingdom, Edinburgh
The University of Edinburgh
Slikas, Elizabeth
United States, San Francisco
Ucsf School of Medicine
United States, San Francisco
Vitalant Research Institute
Li, Linlin
United States, San Francisco
Ucsf School of Medicine
United States, San Francisco
Vitalant Research Institute
Bodhidatta, Ladaporn
Thailand, Bangkok
Armed Forces Research Institute of Medical Sciences, Thailand
Sethabutr, Orntipa
Thailand, Bangkok
Armed Forces Research Institute of Medical Sciences, Thailand
Triki, Henda
Tunisia, Tunis
Institut Pasteur de Tunis
Bahri, Olfa
Tunisia, Tunis
Institut Pasteur de Tunis
Oderinde, Bamidele Soji
Nigeria, Maiduguri
University of Maiduguri
Baba, Maryceline Mandu
Nigeria, Maiduguri
University of Maiduguri
Bukbuk, David Nadeba
United States, Saint Paul
Minnesota Department of Health
Besser, John
United States, Saint Paul
Minnesota Department of Health
Bartkus, Joanne
United States, Saint Paul
Minnesota Department of Health
Delwart, E. L.
United States, San Francisco
Ucsf School of Medicine
United States, San Francisco
Vitalant Research Institute
Statistics
Citations: 340
Authors: 14
Affiliations: 7
Identifiers
Doi:
10.1086/652416
ISSN:
00221899
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Nigeria
Tunisia