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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Confirmed infection with intestinal schistosomiasis in semi-captive wild-born chimpanzees on Ngamba Island, Uganda
Vector-Borne and Zoonotic Diseases, Volume 11, No. 2, Year 2011
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Description
Background: Intestinal schistosomiasis, caused by Schistosoma mansoni, is endemic to Lake Victoria, with high prevalence of the disease observed in human lakeshore communities. However, nonhuman primates have recently been overlooked as potential hosts of the disease, despite known susceptibility. Methods: Using a variety of stool, urine, and serological diagnostic methods, 39 semi-captive wild-born chimpanzees and 37 staff members at Ngamba Island Chimpanzee Sanctuary, Lake Victoria, Uganda, were examined for S. mansoni infection. Miracidia recovered from stool were DNA barcoded to investigate cross-over between humans and chimpanzees. The island was also surveyed for Biomphalaria intermediate host snails, which were examined for infection with S. mansoni. Results: Chimpanzees were unequivocally shown to be infected with intestinal schistosomiasis with a seroprevalence in excess of 90%. Three egg-positive cases were detected, although the sensitivity of the diagnostic tests varied due to earlier prophylactic praziquantel treatment. Miracidia hatched from chimpanzee stool revealed three DNA haplotypes commonly found in humans living throughout Lake Victoria, including staff on Ngamba Island, as well as two novel haplotypes. At one site, a snail was observed shedding schistosome cercariae. Conclusions: The anthropozoonotic potential of intestinal schistosomiasis on Ngamba Island is greater than previously thought. Moreover, the ability of chimpanzees to void schistosome eggs capable of hatching into viable miracidia further suggests that these nonhuman primates may be capable of maintaining a local zoonotic transmission of schistosomiasis independently of humans. The implications for management of captive and wild primate populations at risk of exposure are discussed. © Copyright 2011, Mary Ann Liebert, Inc. 2011.
Authors & Co-Authors
Standley, Claire J.
United Kingdom, London
The Natural History Museum, London
United Kingdom, Nottingham
University of Nottingham
Mugisha, Lawrence
Uganda
Chimpanzee Sanctuary and Wildlife Conservation Trust Cswct
Verweij, Jaco J.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Adriko, Moses
Uganda, Kampala
Uganda Ministry of Health
Arinaitwe, Moses
Uganda, Kampala
Uganda Ministry of Health
Rowell, Candia
Uganda, Kampala
Uganda Ministry of Health
Atuhaire, Aaron
Uganda, Kampala
Uganda Ministry of Health
Betson, Martha E.
United Kingdom, London
The Natural History Museum, London
Hobbs, Emma C.
Uganda
Chimpanzee Sanctuary and Wildlife Conservation Trust Cswct
Van Tulleken, Christoffer R.
United Kingdom, London
The Royal Free Hospital
Kane, Richard A.
United Kingdom, London
The Natural History Museum, London
van Lieshout, Lisette
Netherlands, Leiden
Leids Universitair Medisch Centrum
Ajarova, Lilly
Uganda
Chimpanzee Sanctuary and Wildlife Conservation Trust Cswct
Kabatereine, Narcis B.
Uganda, Kampala
Uganda Ministry of Health
Russell Stothard, John Russell
United Kingdom, London
The Natural History Museum, London
Statistics
Citations: 25
Authors: 15
Affiliations: 6
Identifiers
Doi:
10.1089/vbz.2010.0156
ISSN:
15303667
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Uganda