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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Quantification of the distribution of
111
In-labelled platelets in organs
European Journal of Nuclear Medicine, Volume 7, No. 2, Year 1982
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Description
A simple and practical approach to the in vivo quantification of 111indium-oxine labelled blood platelets with a scintillation camera and computer assisted imaging system was evaluated. Radioactivity of the 172 and 247 keV energies was measured in a phantom at various source distances from the collimator and the accuracy of anterior and posterior mode measurements compared with that of the geometrical mean (GM) method, with and without correction for Compton scatter (CS). Organ radioactivity, expressed as a percentage of whole body radioactivity, was determined in vivo in five baboons and the accuracy of the methods verified by post mortem quantification in the animals. Measurement in the anterior mode significantly overestimates hepatic and underestimates splenic radioactivity; posterior mode quantification reverses these results. Correction with the GM method made the accuracy and reproducibility very acceptable. Further correction for anterior-posterior attenuation and/or CS did not improve results materially. The GM method could readily be applied in five human subjects. This study shows that the GM method is an accurate and practical method for the in vivo quantification of organ and regional distribution of 111In-labelled platelets. © 1982 Springer-Verlag.
Authors & Co-Authors
van Reenen, Otto R.
South Africa, Bloemfontein
Universitas Private Hospital
South Africa, Bloemfontein
University of the Free State
Lötter, Mattheus G.
South Africa, Bloemfontein
Universitas Private Hospital
South Africa, Bloemfontein
University of the Free State
Heyns, Anthon Du P.
South Africa, Bloemfontein
Universitas Private Hospital
South Africa, Bloemfontein
University of the Free State
de Kock, Felicity
South Africa, Bloemfontein
Universitas Private Hospital
South Africa, Bloemfontein
University of the Free State
Herbst, Charles Petrus
South Africa, Bloemfontein
Universitas Private Hospital
South Africa, Bloemfontein
University of the Free State
Kotzè, Harry F.
South Africa, Bloemfontein
Universitas Private Hospital
South Africa, Bloemfontein
University of the Free State
Pieters, Henry
South Africa, Bloemfontein
Universitas Private Hospital
South Africa, Bloemfontein
University of the Free State
Minnaar, Philip C.
South Africa, Bloemfontein
Universitas Private Hospital
South Africa, Bloemfontein
University of the Free State
Badenhorst, Philip Nel
South Africa, Bloemfontein
Universitas Private Hospital
South Africa, Bloemfontein
University of the Free State
Statistics
Citations: 32
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1007/BF00251649
ISSN:
03406997
e-ISSN:
16197089