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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Risk factors for severe rift valley fever infection in Kenya, 2007
American Journal of Tropical Medicine and Hygiene, Volume 83, No. 2 SUPPL., Year 2010
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Description
A large Rift Valley fever (RVF) outbreak occurred in Kenya from December 2006 to March 2007. We conducted a study to define risk factors associated with infection and severe disease. A total of 861 individuals from 424 households were enrolled. Two hundred and two participants (23%) had serologic evidence of acute RVF infection. Of these, 52 (26%) had severe RVF disease characterized by hemorrhagic manifestations or death. Independent risk factors for acute RVF infection were consuming or handling products from sick animals (odds ratio [OR] = 2.53, 95% confidence interval [CI] = 1.78-3.61, population attributable risk percentage [PAR%] = 19%) and being a herdsperson (OR 1.77,95% CI = 1.20-2.63, PAR% = 11%). Touching an aborted animal fetus was associated with severe RVF disease (OR = 3.83,95% CI = 1.68-9.07, PAR% = 14%). Consuming or handling products from sick animals was associated with death (OR = 3.67,95% CI = 1.07-12.64, PAR% = 47%). Exposures related to animal contact were associated with acute RVF infection, whereas exposures to mosquitoes were not independent risk factors. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Anyangu, Amwayi
Kenya, Nairobi
Ministry of Public Health and Sanitation
Gould, L. Hannah
United States, Atlanta
Centers for Disease Control and Prevention
Sharif, Shahnaaz K.
Kenya, Nairobi
Ministry of Public Health and Sanitation
Nguku, Patrick Mboya
Kenya, Nairobi
Ministry of Health Nairobi
Omolo, Jared Odhiambo
Kenya, Nairobi
Ministry of Health Nairobi
Mutonga, David M.
Kenya, Nairobi
Ministry of Health Nairobi
Rao, C. Y.
United States, Atlanta
Centers for Disease Control and Prevention
Lederman, Edith R.
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Schnabel, David C.
Unknown Affiliation
Pawȩska, Janusz Tadeusz
South Africa, Johannesburg
National Institute for Communicable Diseases
Katz, Mark A.
Kenya, Kisumu
Centers for Disease Control and Prevention, Kenya
Hightower, Allen W.
Kenya, Kisumu
Centers for Disease Control and Prevention, Kenya
Njenga, Moses Kariuki
Kenya, Nairobi
Gdd/ieip-kenya
Feikin, Daniel R.
United States, Atlanta
Centers for Disease Control and Prevention
Breiman, Robert F.
Kenya, Nairobi
International Emerging Infections Program
Statistics
Citations: 157
Authors: 15
Affiliations: 9
Identifiers
Doi:
10.4269/ajtmh.2010.09-0293
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Kenya