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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Otorhinolaryngological findings and hearing in HIV-positive and HIV-negative children in a developing country
European Archives of Oto-Rhino-Laryngology, Volume 268, No. 10, Year 2011
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Description
The otorhinolaryngological (ORL) manifestations of Human Immunodeficiency virus (HIV) are common, but remain poorly characterized among children of Sub-Saharan Africa, where 90% of new pediatric infections occur. Our objective was to compare ORL findings and hearing in HIV-positive and -negative children of Luanda, Angola, using a comparative study of 78 outpatients from the HIV polyclinic and of 78 age- and sex-matched controls in a pediatric hospital with interview, general and ORL examination, brainstem auditory evoked potentials, and at age >5 years pure tone open-air audiometry. ORL pathology emerged in 92% of HIV-positive and 78% (p = 0.02) of control children. HIV-associated ORL findings comprised dental caries (56 vs. 32%; p = 0.0009), cervical lymphadenopathy >1 cm (45 vs. 10%; p < 0.0001), facial skin lesions (32 vs. 5.1%; p < 0.0001), chronic suppurative otitis media (26 vs. 3.8%; p = 0.0002), dry tympanic membrane perforations (9 vs. 1%; p = 0.03), tonsils of Mallampati score 0-1 (87 vs. 64%; p = 0.0009), and bilateral hearing loss of >25 dB (13 vs. 1%; p = 0.009). Other HIV-associated characteristics included ear pain (44 vs. 27%; p = 0.006), earlier otorrhea episodes (34 vs. 17%; p = 0.004), tuberculosis (29 vs. 2.6%; p < 0.0001), and pneumonia (22 vs. 2.6%; p = 0.0003). ORL pathology appeared usual in both HIV-positive and -negative children. However, the overall high frequency and severity of the findings among the HIV-positive children require regular inclusion of the ORL area in these children's clinical evaluation. © 2011 Springer-Verlag.
Authors & Co-Authors
Taipale, Anni
Finland, Helsinki
Helsingin Yliopisto
Angola, Luanda
Hospital Pediátrico David Bernardino
Pelkonen, Tuula
Finland, Helsinki
Helsingin Yliopisto
Angola, Luanda
Hospital Pediátrico David Bernardino
Taipale, Marko
Angola, Luanda
Hospital Pediátrico David Bernardino
Finland, Helsinki
Helsingin Yliopisto
Roine, Irmeli
Chile, Santiago
Universidad Diego Portales
Bernardino, Luís
Angola, Luanda
Hospital Pediátrico David Bernardino
Peltola, Heikki O.
Finland, Helsinki
Helsingin Yliopisto
Pitkäranta, Anne
Finland, Helsinki
Helsingin Yliopisto
Statistics
Citations: 54
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1007/s00405-011-1579-x
ISSN:
09374477
e-ISSN:
14344726
Research Areas
Disability
Environmental
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Locations
Angola