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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Natural lysophospholipids reduce Mycobacterium tuberculosis-induced cytotoxicity and induce anti-mycobacterial activity by a phagolysosome maturation-dependent mechanism in A549 type II alveolar epithelial cells
Immunology, Volume 129, No. 1, Year 2010
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Description
Human alveolar epithelial cells actively contribute to the innate immune response in the lung and play an important role in mycobacterial dissemination during primary infection, by undergoing cell death and by releasing mycobacteria. In the present study, we report that natural lysophospholipids, such as lysophosphatidic acid or sphingosine 1-phosphate, reduce Mycobacterium tuberculosis-induced cytotoxicity and enhance anti-mycobacterial activity in the A549 cell line, used as a model of type II alveolar epithelial cells. Intracellular mycobacterial killing was strictly dependent on phagolysosome maturation, which in turn was promoted by the activation of a Ca 2+dependent phospholipase D. Finally, the restriction of mycobacteria in highly microbiocidal compartments was associated, in vitro, with a significant decrease in mycobacterial dissemination to macrophages. Taken as whole, these results suggest that the pulmonary lysophospholipid microenvironment may play a protective role during the early phases of host-pathogen interaction by enhancing anti-mycobacterial activity in type II alveolar epithelial cells. © 2009 Blackwell Publishing Ltd.
Authors & Co-Authors
Papi, Massimiliano
Italy, Rome
Università Cattolica Del Sacro Cuore, Campus Di Roma
De Spirito, Marco D.
Italy, Rome
Università Cattolica Del Sacro Cuore, Campus Di Roma
Delogu, G.
Italy, Rome
Università Cattolica Del Sacro Cuore, Campus Di Roma
Colizzi, Vittorio C.
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Fraziano, Maurizio
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Statistics
Citations: 31
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1111/j.1365-2567.2009.03145.x
ISSN:
13652567