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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population
Human Genetics, Volume 124, No. 5, Year 2008
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Description
Tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) directly influence thrombus formation and degradation, and have been identified as risk factors for thromboembolic disease. Prior studies investigated determinants of t-PA and PAI-1 expression, but mainly in Caucasian subjects. The aim of this study was to identify the contributions of genetic and other factors to inter-individual variation in plasma levels of t-PA and PAI-1 in a large-scale population-based sample from urban West Africa. t-PA, PAI-1 and several demographic, anthropometric, and metabolic parameters were measured in 992 residents of Sunyani, the capital of the Brong-Ahafo region of Ghana. In addition, nine gene polymorphisms associated with components of the renin-angiotensin and fibrinolytic systems were determined. We found that BMI, systolic and diastolic blood pressure, total cholesterol, glucose, and triglycerides were all significant predictors of t-PA and PAI-1 in both females and males. In addition, a significant relationship was found between the PAI-1 4G/5G (rs1799768) polymorphism on PAI-1 levels in females, the TPA I/D (rs4646972) polymorphism on t-PA and PAI-1 in males, the renin (rs3730103) polymorphism on t-PA and PAI-1 in males, the ethanolamine kinase 2 (rs1917542) polymorphism on PAI-1 in males, and the renin (rs1464816) polymorphism on t-PA in females and on PAI-1 in males. This study of urban West Africans shows that t-PA and PAI-1 levels are determined by both genetic loci of the fibrinolytic and renin-angiotensin systems and other factors often associated with cardiovascular disease, and that genetic factors differ between males and females. © Springer-Verlag 2008.
Authors & Co-Authors
Schoenhard, J. A.
United States, Nashville
Vanderbilt University School of Medicine
Asselbergs, Folkert W.
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Poku, Kwabena
Ghana, Accra
University of Ghana Business School
Stocki, S. A.
United States, Hanover
Geisel School of Medicine at Dartmouth
Gordon, S.
Ghana
Regional Hospital
Vaughan, D. E.
United States, Nashville
Vanderbilt University School of Medicine
Brown, Nancy J.
United States, Nashville
Vanderbilt University School of Medicine
Moore, Jason H.
United States, Hanover
Geisel School of Medicine at Dartmouth
Williams, Scott M.
United States, Nashville
Vanderbilt University School of Medicine
United States, Nashville
Vanderbilt University Medical Center
Statistics
Citations: 25
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1007/s00439-008-0573-x
ISSN:
03406717
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Locations
Multi-countries
Ghana
Participants Gender
Male
Female