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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
New strain of human T lymphotropic virus (HTLV) type 3 in a pygmy from Cameroon with peculiar HTLV serologic results
Journal of Infectious Diseases, Volume 199, No. 4, Year 2009
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Description
A search for human T lymphotropic virus (HTLV) types 1 and 2 and related viruses was performed by serological and molecular means on samples obtained from 421 adult villagers from the southern Cameroon forest areas. One individual (a 56-year-old Baka Pygmy hunter) was found to be HTLV-3 infected; however, there was a low proviral load in blood cells. Complete sequence analysis of this virus (HTLV-3Lobak18) indicated a close relationship to human HTLV-3Pyl43 and simian STLV-3CTO604 strains. Plasma samples from Lobak18, the HTLV-3 infected individual, exhibited a peculiar "HTLV-2-like" pattern on Western blot analysis and were serologically untypeable by line immunoassay. These results were different from those for the 2 previously reported HTLV-3 strains, raising questions about serological confirmation of infection with such retroviruses. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Calattini, Sara
France, Paris
Cnrs Centre National de la Recherche Scientifique
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Betsem, Edouard À.
France, Paris
Cnrs Centre National de la Recherche Scientifique
Cameroon, Yaounde
Université de Yaoundé I Faculté de Médecine
Bassot, Sylviane
France, Paris
Cnrs Centre National de la Recherche Scientifique
Chevalier, Sébastien Alain
France, Paris
Cnrs Centre National de la Recherche Scientifique
Mahieux, Renaud
France, Paris
Cnrs Centre National de la Recherche Scientifique
United States, Washington, D.c.
George Washington University Medical Center
Froment, Alain
France, Paris
Museé de L'homme
Gessain, Antoine
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 49
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1086/596206
ISSN:
00221899
Study Locations
Cameroon