Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Outcome of older patients receiving mechanical ventilation
Intensive Care Medicine, Volume 30, No. 4, Year 2004
Notification
URL copied to clipboard!
Description
Objective: To determine the threshold of age that best discriminates the survival of mechanically ventilated patients and to estimate the outcome of mechanically ventilated older patients. Design: International prospective cohort study. Setting: Three hundred sixty-one intensive care units from 20 countries. Patients and participants: Five thousand one hundred eighty-three patients mechanically ventilated for more than 12 h. Interventions: None. Measurements and results: Recursive partitioning and logistic regression were used and an outcome model was derived and validated using independent subgroups of the cohort. Two age thresholds (43 and 70 years) were found, by partitioning recursive analysis, to be associated with outcome. This study focuses on the analysis of patients older than 43 years of age, divided in two subgroups: between 43 and 70 years (middle age group) and older than 70 years (elderly group). Survival in hospital was 45% (95% C.I.: 43-48) for the elderly group and 55% (53-57) for the middle age group (p<0.001). Advanced age was not associated with prolongation of mechanical ventilation, weaning or length of stay in the ICU and in hospital (p>0.05). Variables associated with mortality in the elderly were: acute renal failure, shock, Simplified Acute Physiology Score II and a ratio of PaO2 to FIO2 more than 150. Conclusions: Older mechanically ventilated patients (age >70 years) had a lower ICU and hospital survival, but the duration of mechanical ventilation, ICU and hospital stay were similar to younger patients. Factors associated with the highest risk of mortality in patients older than 70 were the development of complications during the course of mechanical ventilation, such as acute renal failure and shock. © Springer-Verlag 2004.
Authors & Co-Authors
Esteban, Andrés
Spain, Getafe
Hospital Universitario de Getafe
Anzueto, Antonio R.
United States, San Antonio
The University of Texas at San Antonio
Frutos-Vivar, Fernando
Spain, Getafe
Hospital Universitario de Getafe
Alia, Inmaculada Moreno
Spain, Getafe
Hospital Universitario de Getafe
Ely, Eugene Wesley
United States, Nashville
Vanderbilt University
Brochard, Laurent Jean
France, Creteil
Hôpital Henri Mondor
Stewart, Thomas E.
Canada, Toronto
University Health Network University of Toronto
Apezteguía, Carlos J.
Argentina, Buenos Aires
Hospital Profesor Posadas
Tobin, Martin J.
United States, Chicago
Loyola University Chicago
Nightingale, Peter N.
United Kingdom, Manchester
Manchester University Nhs Foundation Trust
Matamis, Dimitrios
Greece, Thessaloniki
Papageorgiou General Hospital
Pimentel, Jorge Manuel
Portugal, Coimbra
Centro Hospitalar e Universitário de Coimbra
Abrouk, Fekri
Tunisia, Monastir
Chu Fattouma-bourguiba
Statistics
Citations: 114
Authors: 13
Affiliations: 11
Identifiers
Doi:
10.1007/s00134-004-2160-5
ISSN:
03424642
Research Areas
Health System And Policy
Study Design
Cohort Study
Study Approach
Quantitative