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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Incidence of Parkinson disease in North America
npj Parkinson's Disease, Volume 8, No. 1, Article 170, Year 2022
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Description
Parkinson disease (PD) is the second most common age-related neurodegenerative condition diagnosed in North America. We recently demonstrated, using multiple epidemiological data sources, that the prevalence of PD diagnoses was greater than previously reported and currently used for clinical, research, and policy decision-making. Prior PD incidence estimates have varied, for unclear reasons. There is a need for improved estimates of PD incidence, not only for care delivery planning and future policy but also for increasing our understanding of disease risk. The objective of this study was thus to investigate the incidence of Parkinson disease across five epidemiological cohorts in North America in a common year, 2012. The cohorts contained data on 6.7 million person-years of adults ages 45 and older, and 9.3 million person-years of adults ages 65 and older. Our estimates of age-sex-adjusted incidence of PD ranged from 108 to 212 per 100,000 among persons ages 65 and older, and from 47 to 77 per 100,00 among persons ages 45 and older. PD incidence increased with age and was higher among males. We also found persistent spatial clustering of incident PD diagnoses in the U.S. PD incidence estimates varied across our data sources, in part due to case ascertainment and diagnosis methods, but also possibly due to the influence of population factors (prevalence of genetic risk factors or protective markers) and geographic location (exposure to environmental toxins). Understanding the source of these variations will be important for health care policy, research, and care planning. © 2022, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC9755252/bin/41531_2022_410_MOESM1_ESM.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC9755252/bin/41531_2022_410_MOESM2_ESM.pdf
Authors & Co-Authors
Willis, Allison W.
United States, Philadelphia
University of Pennsylvania
Beck, James C.
Unknown Affiliation
Fiske, Brian K.
United States, New York
The Michael J. Fox Foundation for Parkinson‘s Research
van den Eeden, Stephen K.
United States, Oakland
Kaiser Permanente
Tanner, Caroline M.
United States, San Francisco
University of California, San Francisco
Marras, Connie
Canada, Toronto
University of Toronto
Alcalay, Roy N.
Unknown Affiliation
Schwarzschild, Michael A.
Unknown Affiliation
Racette, Brad A.
Unknown Affiliation
Statistics
Citations: 47
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1038/s41531-022-00410-y
ISSN:
23738057
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study
Cohort Study